CCR7

CCR7. also known as Epstein-Barr virw-y-induced gene 1 (EBI1) or Burkitt’s lymphoma receptor 2 (BLR2>. was originally identified as an orphan G protein-coupled receptor. Later, it was found to be a receptor for the CC chemokines ELC/MIP-3tf and SLC, 6Ckine. CCR7 is mainly expressed on lymphocytes and dendritic cells, and is important in migration of these types of cells to secondary lymphoid tissues. CCR7 may also be involved in viral pathogenesis since the expression of CCR7 is upregulated by infection of lymphocytes and dendritic cells, and is important in migration of these types of cells to secondary lymphoid tissues. CCR7 may also be involved in viral pathogenesis since the expression of CCR7 is upregulated by infection of dendritic cells, and is important in migration of these cell types to secondary lymphoid tissues. CCR7 may also be involved in viral pathogenesis since the expression of CCR7 is upregulated by infection of cells with Epstein-В orr virus (EBV) and T cells with /n/man herpesvirus (HHV) types 6 and 7. The human gene for CCR7 is located on human chromosome 17cj 12-u.21.2.