Zinc Enzyme Inhibitors: Enzymes from Microorganisms (Topics in Medicinal Chemistry (22))

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. Front Matter....Pages i-ix An Elusive Task: A Clinically Useful Inhibitor of Metallo-β-Lactamases....Pages 1-34 Inhibitors of Histidinol Dehydrogenase....Pages 35-46 Botulinum Neurotoxin, Tetanus Toxin, and Anthrax Lethal Factor Countermeasures....Pages 47-67 Inhibition and Activity Regulation of Bacterial Collagenases....Pages 69-94 Fungal Carbonic Anhydrases and Their Inhibition....Pages 95-110 Protozoan Carbonic Anhydrases....Pages 111-133 Bacterial Carbonic Anhydrases....Pages 135-152 Back Matter....Pages 153-156