Wilson & Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry (WILSON AND GISVOLD'S TEXTBOOK OF ORGANIC AND PHARMACEUTICAL CHEMISTRY)

For over half a century, this book has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Eleventh Edition, coverage begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications. This Textbook Integrates The Chemical And Pharmaceutical Principles Necessary To Understand Structure-activity Relationships And The Molecular Mechanisms Of Drug Action. In 28 Chapters, Medicinal Chemists, Pharmacists, And Other Scientists Discuss Topics Like Combinatorial Chemistry, Biotechnology, Immunobiologicals, Anti- Infective Agents, Antimalarials, Antibiotics, Antiviral Agents, Antineoplastic Agents, Diagnostic Imaging, Depressants, Stimulants, Adrenergic, Diuretics, Cardiovascular Agents, Local Anesthetics, Steroids, Peptide Hormones, Vitamins, Herbs, And Computational Chemistry And Computer-assisted Drug Design. Introduction / John H. Block And John M. Beale, Jr. -- Physicochemical Properties In Relation To Biological Action / John H. Block -- Combinatorial Chemistry / Douglas R. Henry -- Metabolic Changes Of Drugs And Related Organic Compounds / Stephen J. Cutler And John H. Block -- Prodrugs And Drug Latentiation / Forrest T. Smith And C. Randall Clark -- Biotechnology And Drug Discovery / John M. Beale, Jr. -- Immunobiologicals / John M. Beale, Jr. -- Anti-infective Agents / John M. Beale, Jr. -- Antimalarials / John H. Block -- Antibacterial Antibiotics / John M. Beale, Jr. -- Antiviral Agents / John M. Beale, Jr. -- Antineoplastic Agents / William A. Remers -- Agents For Diagnostic Imaging / Tim B. Hunter, T. Kent Walsh, Jack N. Hall. Central Nervous System Depressants / Eugene I. Isaacson -- Central Nervous System Stimulants / Eugene I. Isaacson -- Adrenergic Agents / Rodney L. Johnson -- Cholinergic Drugs And Related Agents / George H. Cocolas And Stephen J. Cutler -- Diuretics / Daniel A. Koechel -- Cardiovascular Agents / Stephen J. Cutler And George H. Cocolas -- Local Anesthetic Agents / Gareth Thomas -- Histamine And Antihistaminic Agents / Thomas N. Riley And Jack Deruiter -- Analgesic Agents / Robert E. Willette -- Steroids And Therapeutically Related Compounds / Philip J. Proteau -- Prostaglandins, Leukotrienes, And Other Eicosanoids / Thomas J. Holmes, Jr. -- Proteins, Enzymes, And Peptide Hormones / Stephen J. Cutler And Horace G. Cutler -- Vitamins And Related Compounds / Gustavo R. Ortega, Michael J. Deimling, And Jaime N. Delgado -- An Introduction To The Medicinal Chemistry Of Herbs / John M. Beale, Jr. -- Computational Chemistry And Computer Assisted Drug Design / J. Phillip Bowen. Edited By John H. Block, John M. Beale Jr. Includes Bibliographical References And Index.