Vitamin D Analogs In Cancer Prevention And Therapy (recent Results In Cancer Research)

This volume provides a comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer. Front Matter....Pages I-VIII Front Matter....Pages 1-1 Evolution and Function of Vitamin D....Pages 3-28 Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands....Pages 29-42 Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk....Pages 43-54 Ligand Structure—Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment)....Pages 55-82 Antiproliferative Signalling by 1, 25(OH) 2 D 3 in Prostate and Breast Cancer Is Suppressed by a Mechanism Involving Histone Deacetylation....Pages 83-98 Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells....Pages 99-110 Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH) 2 D 3 : Why?....Pages 111-122 A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis....Pages 123-134 Extrarenal Sites of Calcitriol Synthesis:The Particular Role of the Skin....Pages 135-145 Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1α-Hydroxylase....Pages 147-149 Gene Amplification and Splice Variants of 25-Hydroxyvitamin D 3 1, α-Hydroxylase (CYP27B1) in Glioblastoma Multiforme— A Possible Role in Tumor Progression?....Pages 151-155 Regulation of the 25-Hydroxyvitamin D-1α-Hydroxylase Gene and Its Splice Variant....Pages 157-167 Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism....Pages 169-188 Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs....Pages 189-202 Front Matter....Pages 203-203 The Role of Vitamin D in Prostate Cancer....Pages 205-221 Vitamin D Autocrine System and Prostate Cancer....Pages 223-237 Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer....Pages 239-246 Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor—Butyrate Connection....Pages 247-257 Analysis of the Vitamin D system in Cutaneous Malignancies....Pages 259-269 Front Matter....Pages 271-271 Evaluation of Vitamin D Analogs as Therapeutic Agents for Prostate Cancer....Pages 273-288 Front Matter....Pages 271-271 Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D 3 Analogs....Pages 289-317 Induction of Apoptosis by Vitamin D Metabolites and Analogs in a Glioma Cell Line....Pages 319-332 Vitamin D Analogs and Breast Cancer....Pages 333-348 A Low-Calcemic Vitamin D Analog (Ro 25-4020) Inhibits the Growth of LNCaP Human Prostate Cancer Cells with Increased Potency by Producing an Active 24-Oxo Metabolite (Ro 29-9970)....Pages 349-352 Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases....Pages 353-356 The Role of Reactive Oxygen Species in the Anticancer Activity of Vitamin D....Pages 357-367 Front Matter....Pages 369-369 Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates....Pages 371-377 Phytoestrogens and 17β-Estradiol Influence Vitamin D Metabolism and Receptor Expression—Relevance for Colon Cancer Prevention....Pages 379-391 Efficacy and Mechanism of Action of 1α-hydroxy-24-ethyl-Cholecalciferol (1α[OH]D5) in Breast Cancer Prevention and Therapy....Pages 393-411 Regulation of Extrarenal Vitamin D Metabolism as a Tool for Colon and Prostate Cancer Prevention....Pages 413-425 Modulation of X-ray-Induced Apoptosis in Human Keratinocytes (HaCaT) by 1,25-Dihydroxyvitamin D 3 ....Pages 427-432