Visual Dysfunction in Diabetes: The Science of Patient Impairment and Health Care (Ophthalmology Research)

An exciting contribution to the field, __Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement__is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, __Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement__offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, __Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement__ offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes. An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes. Front Matter....Pages i-xv Front Matter....Pages 1-1 Living with Diabetic Retinopathy: The Patient’s View....Pages 3-14 Front Matter....Pages 15-15 Diabetic Retinopathy Screening: Progress or Lack of Progress....Pages 17-29 Functional/Neural Mapping Discoveries in the Diabetic Retina: Advancing Clinical Care with the Multifocal ERG....Pages 31-42 Front Matter....Pages 43-43 Corneal Diabetic Neuropathy....Pages 45-51 Clinical Phenotypes of Diabetic Retinopathy....Pages 53-68 Visual Psychophysics in Diabetic Retinopathy....Pages 69-103 Mechanisms of Blood–Retinal Barrier Breakdown in Diabetic Retinopathy....Pages 105-122 Molecular Regulation of Endothelial Cell Tight Junctions and the Blood-Retinal Barrier....Pages 123-141 Capillary Degeneration in Diabetic Retinopathy....Pages 143-155 Proteases in Diabetic Retinopathy....Pages 157-172 Proteomics in the Vitreous of Diabetic Retinopathy Patients....Pages 173-188 Neurodegeneration in Diabetic Retinopathy....Pages 189-209 Glucose-Induced Cellular Signaling in Diabetic Retinopathy....Pages 211-232 IGFBP-3 as a Regulator of the Growth-Hormone/Insulin-Like Growth Factor Pathway in Proliferative Retinopathies....Pages 233-244 Neurotrophic Factors in Diabetic Retinopathy....Pages 245-259 The Role of CTGF in Diabetic Retinopathy....Pages 261-285 Front Matter....Pages 285-285 Ranibizumab and Other VEGF Antagonists for Diabetic Macular Edema....Pages 289-306 Neurodegeneration, Neuropeptides, and Diabetic Retinopathy....Pages 307-323 Glial Cell–Derived Cytokines and Vascular Integrity in Diabetic Retinopathy....Pages 325-338 Impact of Islet Cell Transplantation on Diabetic Retinopathy in Type 1 Diabetes....Pages 339-365 Back Matter....Pages 367-379 This book helps readers understand the impact of vision impairment in people living with diabetes, rather than seeing diabetic retinopathy solely as a medical problem, and explores what we know and don't know about the ways diabetes affect the eye. ISBN-13: 978-1-60761-149-3 ISBN-10:,1-60761-149-X ISBN-10: 1-60761-149-X