Viruses, Immunity, and Immunodeficiency (University of South Florida International Biomedical Symposia Series)

This publication, "Viruses, Immunity and Immunodeficiency," is based on the first symposium in a series of International Biomedical Symposia sponsored by the College of Medicine of the University of South Florida in Tampa, Florida. There is an explosive interest concerning the effects of viruses on the immune response, especially the immunosuppressive effects of viral infection. This has come about because of the recognition that the Acquired Immunodeficiency Syndrome, which has taken biomedical scientists and the public in general by surprise, is just one of the many examples that viruses can influence the immune response system and, under appropriate circumstances, alter immunity in such a way that an infected individual becomes hi~lly susceptible to a variety of other organisms to which normal individuals would be resistant. This symposium series, sponsored by the University of South Florida College of Medicine, brings to the biomedical con®unity topics of current interest. We thank the members of the faculty of various departments of the College of Medicine and the administration of the College for their support and encouragement in having these symposiaat this medical school. This volume, based or. this symposium onviruses and immunity is a good exam­ ple of the interdisciplinary nature of modern irrJ!1I1nobiology and modern biomedical science in general. Many investigators with many different back­ grounds and training experiences, including microbiologists, immunologists, biochemists, oncologists, and physicians, are interested in how and why viruses influence the immune response system. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Natural Resistance Mechanisms in Herpesvirus Infections....Pages 3-11 Macrophages and Genetically Determined Natural Resistance to Virus Infections....Pages 13-24 Virus Interactions with the Immune Defense System....Pages 25-39 Front Matter....Pages 41-41 Epstein-Barr Virus (EBV) and Immunodeficiencies....Pages 43-48 Depressive Effect of Epstein-Barr Virus Transformed Cell Fractions on Responsiveness of Human Leukocytes to Mitogens....Pages 49-58 Cytomegalovirus Infection and the Immune System....Pages 59-66 Immunologic Findings in a Case of Congenital CMV Compared to Infants with Aids....Pages 67-72 Herpes Simplex Virus and Immunity....Pages 73-79 `Hepatitis B Virus, Iron and Iron-Binding Proteins....Pages 81-99 The Immune System in Experimental Coxsackievirus—B3 Infection....Pages 101-105 Front Matter....Pages 107-107 Mammary Tumor Virus Infections and Immunity....Pages 109-122 Mouse Mammary Tumor Virus and Human Breast Cancer: Relationship of Presence of gp52 in Breast Tissue to Circulating Antibody to MuMTV....Pages 123-128 Retrovirus-Induced Immunodeficiency in Mice....Pages 129-140 Immunosuppression by Human and Feline Retroviruses....Pages 141-149 Virus Interactions with the Host: Past, Present and Future Developments....Pages 151-158 Viruses, Cancer and Immunity....Pages 159-167 Front Matter....Pages 169-169 Viruses, Genetics and Autoimmunity....Pages 171-182 Molecular Mimicry and Autoimmunity....Pages 183-187 The Acquired Immunodeficiency Syndrome: What Can It Teach Us?....Pages 189-195 Coxsackievirus B, Lipids and Immunity as Shared Determinants in Diabetes and Atherosclerosis....Pages 197-204 Front Matter....Pages 169-169 Mechanism of “Modified-Self” Induced Anti-Herpes Simplex Virus (HSV) Antibody Unresponsiveness....Pages 205-209 Virus Associated Immune and Pharmacologic Mechanisms in Disorders of Respiratory and Cutaneous Atopy....Pages 211-244 Scrapie Infection in Athymic and Germ-Free Mice....Pages 245-249 Age and Gender Related Changes in Normal Levels of Circulating Human Immune Cells....Pages 251-255 Effect of Reagent Source, Processing Techniques, and Sample Storage on Determination of Circulating Human Immune Cells....Pages 257-263 Front Matter....Pages 265-265 Immunorestoration of Immunodeficiency by Biological Response Modifiers....Pages 267-285 Endogenous Immunomodulators from Human Leukocytes as Agents for Immunorestoration in Patients with Aids....Pages 287-299 Interferons and Their Roles in Virus Infections....Pages 301-306 Exacerbation of the Pathogenesis of the Diabetogenic Variant of Encephalomyocarditis Virus in Mice by Interferon....Pages 307-311 Thymic Hormones in Viral Infections and Aids....Pages 313-319 Specific Anti-Influenza Antibody Synthesis and Aging: In Vitro Effects of Thymosin....Pages 321-325 Studies of Bone Marrow and Sera of Cats Recovering from Leukemia Following Protein A Therapy....Pages 327-332 Synergistic Anti-Tumor Effect of an Immunopotentiator (PAV) and an Inhibitor (Cimetidine) of T-Suppressor Cells....Pages 333-336 Immunomodulation by a Polyantigenic Vaccine (PAV) in Patients with Acquired Immunodeficiencies....Pages 337-340 Viruses, Immunity, Immunodeficiency and Cancer....Pages 341-348 Back Matter....Pages 349-365