Virus Infections And Diabetes Mellitus (developments In Medical Virology)

This volume in the series Developments in Medical Virology deals with viruses involved in diabetes mellitus, a syndrome with a strong genetic background that causes damage to the regulation of insulin synthesis and function. Viruses were found either to cause or to stimulate diabetes mellitus in man and in animal models. The nature of the role of viruses is described by many of the scientists who participated in the original studies. To complete the picture, chapters were included that deal with the insulin gene, the secondary structure of the proinsulin and insulin receptor polypeptides, pancreatic Langerhans islets, and clinical considerations of the disease. The aim of Developments in Medical Virology is to elucidate processes involving viruses as pathogens of cells and organisms, with special attention to human diseases. A number of volumes will be devoted to viruses affecting specific organs (e.g. brain, liver, etc.), while others will elaborate on the clinical experience in the use of antiviral drugs. The series is published in parallel with Developments in Molecular Virology, designed to present an analysis of molecular mechanisms implicated in virus infection and replicative processes. In addition, the series Developments in Veterinary Virology provides information on viruses causing diseases in animals, with special emphasis on aspects of interest to veterinarians. Front Matter....Pages i-xiii Front Matter....Pages 1-1 A Polymorphic Locus Near the Human Insulin Gene Associated with Insulin-Dependent Diabetes Mellitus....Pages 3-16 Computerized Chou-Fasman Secondary Structure Analyses of Proinsulin, Insulin and Insulin Receptor Polypeptides....Pages 17-42 Monoclonal Antibodies to Pancreatic Langerhans Islets: Immuno-Chemistry and Applications....Pages 43-71 A Method for Long-Term Maintenance of Fibroblast-Free Glucose-Sensitive Islet Cell Monolayers from Adult Rats....Pages 73-85 Front Matter....Pages 87-87 Clinical Aspects of Diabetes Type I and Type II....Pages 89-109 Autoimmunity in Diabetes....Pages 111-124 Front Matter....Pages 125-125 Islet Cell Antibodies in Children with Mumps Infection....Pages 127-142 Herpes Virus Infections in Human Pancreas Islets and Animal Models....Pages 143-160 Pancreatic Cell Damage in Children with Fatal Viral Infections....Pages 161-174 Coxsackie B4-Induced Pancreopathy....Pages 175-187 Diabetes Mellitus Associated with Epidemic Infectious Hepatitis in Nigeria....Pages 189-200 Human Venezuelan Equine Encephalitis and Diabetes....Pages 201-205 Front Matter....Pages 207-207 Virus-Induced Diabetes in Mice....Pages 209-231 The Interferon System in Encephalomyocarditis (EMC) Virus-Induced Diabetes Mellitus....Pages 233-244 Front Matter....Pages 245-245 Viral Mechanisms Leading to Diabetes Mellitus — A Summary....Pages 247-254 Back Matter....Pages 255-264