Vascular and Neurological Changes in Early Diabetes. Advances in Metabolic Disorders, Supplement 2

Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries. Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful. Content: ADVANCES IN METABOLIC DISORDERS , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Pages xi-xx Preface , Page xxi , Rafael A. Camerini-Dávalos, Harold S. Cole Acknowledgments , Page xxiii , Rafael A. Camerini-Dávalos, Stefan S. Fajans, Rachmiel Levine, Knud Lundbaek Macroangiopathy — Its Prevalence in Asymptomatic Diabetes , Pages 3-9 , H. Keen, R.J. Jarrett The Prevalence of Asymptomatic Diabetes in Human Atherosclerosis , Pages 11-18 , Kenneth J. Kingsbury A Search for Macroangiopathy in Patients with Latent Diabetes , Pages 19-28 , Stefan S. Fajans, Peter N. Weissman, Park W. Willis III,, John C. Floyd Jr., Sumer Pek, J.W. Conn Angiopathy and Neuropathy in Mild Juvenile Diabetes , Pages 29-40 , Klaus Johansen The Role of Insulin in the Development of Atherosclerosis , Pages 41-47 , Robert W. Stout Effect of Insulin on Lipid Metabolism of Human Arteries , Pages 49-53 , Robert Mahler Glucose Lipogenesis in Rabbit Aorta in Relation to Age, Degree of Atherosclerosis, and the Presence of Insulin , Pages 55-66 , Sören Björkerud Hypertriglyceridemia in Early Diabetes , Pages 67-72 , Edwin L. Bierman Altered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, Michigan , Pages 73-81 , Leon D. Ostrander Jr., Walter D. Block, Donald E. Lamphiear, Frederick H. Epstein Insulin, Glucose and Lipid Levels in Mild Diabetics in Relation to Complications , Pages 83-101 , Russell Fraser, C. Lowy, R.S. Elkeles, B. Lewis, M. Mancini Studies in the Functional Properties of Vascular Mucopolysaccharides , Pages 103-110 , S. Gerö, Magdolna Bihari-Varga, S. Virág Proline Hydroxylase in Injury-Induced Arteriosclerosis , Pages 111-116 , George C. Fullesr, Harold L. Crossley Polyol Pathway Activity in Aorta , Pages 117-127 , Albert I. Winegrad, Anthony D. Morrison, RexS. Clements Jr Diabetic Macroangiopathy: Blood Flow and Radiological Studies , Pages 129-135 , Niels Juel Christensen Genetic Transmission of Vasculopathy in KK Mice , Pages 139-145 , Werner Oppermann, Hisashi Iwatsuka, Carlos Velasco, Anne Kellogg, Rafael A. Camerini-Dávalos The Metabolism of the Isolated Renal Glomerulus and Its Basement Membranes , Pages 147-153 , Peter Wahl, Dieter Deppermann, Wendel Deschner, Erhard Fuchs, Walter Rexroth Serum Glycoprotein Disturbances and Their Rheological Effects in Diabetes Mellitus , Pages 155-166 , Donald E. McMillan Biochemical Properties of Human Glomerular Basement Membrane in Normal and Diabetic Kidneys , Pages 167-177 , Nicholas A. Kefalides Biochemistry of the Glomerular Basement Membrane in Diabetes , Pages 179-190 , Robert G. Spiro Growth Hormone and Diabetic Angiopathy , Pages 191-205 , Knud Lundbaek Comparative Metabolie and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics , Pages 207-213 , Thomas J . Merimee Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients , Pages 215-225 , R.F. Knopf, S.S. Fajans, Sumer Pek, John C. Floyd Jr., V.K. Prchkov, J.W. Conn Plasma Epinephrine and Plasma Norepinephrine Concentrations in Early Diabetes , Pages 227-234 , Niels Juel Christensen Microangiopathy and Early Diabeticlike Sugar Tolerances in Animals with Induced Thyroid Immunity , Pages 235-243 , B.N. Premachandra, I.I. Ibrahim Microangiopathy in the Experimentally Diabetic Animal , Pages 245-250 , J.M.B. Bloodworth Jr., R.L. Engermant, P.J. Anderson Vascular Changes Accompanying Dysmetabolism in Rabbits , Pages 251-256 , Bruno W. Volk, Klaus F. Wellmann Microvascular Alterations in Chronically Streptozotocin-Diabetic Rats , Pages 257-269 , D.P. Cameron, M. Amherdt, P. Leuenberger, L. Orci, W. Stauffacher Ultrastructure of Glomerular Lesions in KK Mice , Pages 271-280 , Theodore Ehrenreich, Yasunosuke Susuki, Jacob Churg, Werner Oppermann, Rafael A. Camerini-Dávalos Related Factors in the Progression of Microangiopathy in KK Mice , Pages 281-290 , Werner Oppermann, Theodore Ehrenreich, Dhanoo Patel, Tanya Espinoza, Rafael A. Camerini-Dévalos Microangiopathy in Animals with Spontaneous Diabetes , Pages 291-294,294A,295-298 , M.G. Soret, W.E. Dulin, G.C. Gerritsen Retinal and Renal Microangiopathy in Carp with Spontaneous Diabetes Mellitus , Pages 299-309 , Motoyoshi Yokote Diabetic Basement Membranelike Changes Demonstrable in Peripheral Blood Lymphocytes , Pages 311-315 , Zdenko Škrabalo Ophthalmoscopic Findings and Changes in Hormonal and Metabolic Parameters in “Protodiabetes” , Pages 317-322 , Margret Pfeiffer, J. Birk, J.D. Faulhaber, H. Laube, S. Pal, G. Rothenbuchner, M. Schleyer, K.E. Schroedes Kidney Structural Abnormalities in Early Diabetes , Pages 323-340 , Ruth Østerby The Capillaries of South African Diabetics in Perspective , Pages 341-347 , Ralph E. Yodaiken Diabetic Microangiopathy: Electron Microscope Findings in Human Muscle , Pages 349-355 , Marvin D. Sipersten Capillary Basement Membrane Thickness in Early Diabetes , Pages 357-361 , D. Pometta, M. Amherdt, C. Rufener, J.R. Scherrer Early Capillary Basement Membrane Changes in Subjects with Diabetes Mellitus , Pages 363-371 , Joseph R. Williamson, Nancy J. Vogler, Charles Kilo Deterioration of Tolerance to Glucose and Progression of the Microangiopathy: Effect of Treatment (Preliminary Report) , Pages 373-382 , Rafael A. Camerini-Dávalos, J.M.B. Bloodworth Jr., Baldur Limburg, Arthur L. Gordon, Harold S. Cole, Werner Oppermann Microvascular Changes in Early Diabetes Mellitus , Pages 383-392 , Walter Redisch, Lawrence R. Rouen, Erwin N. Terry, Werner Oppermann, Frantisek Kuthan, Roy H. Clauss Basement Membrane Thickening in Latent Diabetes , Pages 393-399 , Stefan S. Fajans, Joseph R. Williamson, Peter N. Weissman, Nancy J. Vogler, Charles Kilo, J.W. Conn The Microvascular Complications of Early Diabetes in the Pima Indians , Pages 401-413 , Peter H. Bennett, Max Miller Role of Sorbitol Pathway in Neuropathy , Pages 417-424 , Kenneth H. Gabbay The Polyol Pathway in the Neuropathy of Early Diabetes , Pages 425-432 , J.D. Ward Nervous Abnormalities in Early Diabetes , Pages 433-439 , Niels Juel Christensen Ultrastructural Pathology of Peripheral Nervous System in Early Diabetes , Pages 441-449 , A. Bischoff Neurological Findings in Chemical Diabetes , Pages 451-457 , Isaac Faerman, Dora Fox, Mauricio N. Jadzinsky, Leticia Glocer, Jose B. Cibeira Neurological Changes in Early Diabetes , Pages 459-464 , Max Ellenberg Clinical Features of Peripheral Neuropathy ässociated with Hypoglycemia , Pages 465-479 , Gytis Danta Effect of Hypophysectomy and Growth Hormone Treatment on the Composition of Canine Aorta , Pages 483-491 , O.V. Sirek, Margaret E. Brosnan, Anna Sirek Cardiovascular Complications in Diabetics , Pages 493-499 , Mariano Garcia, Patricia McNamara, Tavia Gordon, William B. Kannel Therapy of Early Diabetes: The University Group Diabetes Program , Pages 501-520 , Thaddeus E. Prout Borderline Diabetics and Their Response to Tolbutamide , Pages 521-531 , H. Keen, R.J. Jarrett, J.D. Ward, J.H. Fuller Long-Term Treatment of Patients with Abnormal Intravenous Glucose Tolerance after Myocardial Infarction , Pages 533-538 , J. Paasikivi Vascular Disease in Diabetes and the Effect of Oral Antidiabetic Agents , Pages 539-547 , Alexander Marble Treatment of Chemical Diabetes with Chlorpropamide and the Associated Mortality , Pages 549-555 , John M. Stowers Progress Report on the Prophylactic Use of Oral Hypoglycemie Drugs in Asymptomatic Diabetes: Neurovascular Studies , Pages 557-567 , Robert Feldman, Derek Crawford, Robert Elashoff, Alvin Glass Improvement in Motor Nerve Conduction Following Treatment in Newly Diagnosed Diabetics , Pages 569-573 , J.D. Ward The Effects of Metformin on Lipid-Induced Atherosclerosis , Pages 575-586 , R. Agid, G. Marquié Subject Index , Pages 587-596