Validamycin and Its Derivatives : Discovery, Chemical Synthesis, and Biological Activity

__Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity__ presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications. Front Cover -- Validamycin and Its Derivatives -- Copyright Page -- Contents -- 1 An Introduction to Validamycins and Their Derivatives -- 1.1 Importance of Antibiotics -- 1.2 Agricultural Antibiotics for Plant Pathogens -- 1.3 Validamycins: Magic Agricultural Antibiotics -- 1.4 Aims of the Work -- References -- 2 Production of Validamycins -- 2.1 Discovery of Validamycins -- 2.2 Microbes for Producing Validamycins -- 2.2.1 General Characteristics for Microbes -- 2.2.2 Complete Genomes for the Two Microbes -- 2.2.2.1 General Features of the S. hygroscopicus var. jinggangensis 5008 Genome -- 2.2.2.2 General Features of the S. hygroscopicus subsp. limoneus KCTC 1717 Genome -- 2.3 Production and Isolation of Validamycins and Related Natural Compounds -- 2.3.1 Fermentation of Validamycins -- 2.3.1.1 Temperature of Submerged Culture -- 2.3.1.2 Effect of Medium Volume on Validamycin Production -- 2.3.1.3 Effect of Medium Composition on Validamycin Production -- 2.3.2 Isolation of Validamycins From the Broth -- 2.4 Structures, Characterization, and Properties of Validamycins and Related Natural Compounds -- 2.4.1 Structures of Validamycins and Related Natural Compounds -- 2.4.2 Characterization of Validamycins and Validoxylamines -- 2.4.3 Characterization of Valienamine, Validamine, Valiolamine, and Hydroxyvalidamine -- 2.5 Biosynthesis of Validamycins -- 2.6 Detection of Validamycin A -- 2.6.1 Reversed Layer Method -- 2.6.1.1 Procedure of Reversed Layer Method -- 2.6.2 Colorimetric Method -- 2.6.3 Gas Chromatography -- 2.6.4 HPLC with Reverse Phase Chromatography -- 2.6.5 Liquid Chromatography with Ion Exchange Chromatography -- 2.6.6 Capillary Zone Electrophoresis -- 2.6.7 Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry -- 2.7 Microbial Degradation of Validamycin A

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.

Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.

Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.

Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

• Offers complete coverage of validamycin chemistry from a highly experienced team of authors
• Encourages the discovery of further novel drugs based on validamycin derivatives
• Presents an interesting model for establishing new pharmaceutical leads from agricultural sources
• Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines

Content: Front-matter,CopyrightEntitled to full textChapter 1 - An Introduction to Validamycins and Their Derivatives, Pages 1-8 Chapter 2 - Production of Validamycins, Pages 9-113 Chapter 3 - Bioactivities of Validamycins and Related Natural Compounds, Pages 115-164 Chapter 4 - Chemical Synthesis of Validamycin and Related Natural Compounds, Pages 165-235 Chapter 5 - Voglibose: An Important Drug for Type 2 Diabetes, Pages 237-278 Chapter 6 - N-Octyl-β-Valienamine and N-Octyl-4-epi-β-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy, Pages 279-311 Chapter 7 - Prospects and Concluding Remarks, Pages 313-314 Index, Pages 315-330