Vaccine Design: The Role Of Cytokine Networks (nato Science Series A:)

**`**This book should be very valuable to anyone interested in the basic design of vaccine strategies or the preclinical evaluation of novel vaccines and adjuvants.**'****Doody's Journal****`**I have little doubt that this book will become a standard reference for future development of vaccine formulations.**'****European Journal of Pharmaceutics and Biopharmaceutics Vaccine****Design.** Front Matter....Pages i-ix The Role of Cytokines in the Action of Immunological Adjuvants....Pages 1-9 The Role of Tumour Necrosis Factor in Lymphoid Tissue Formation and Function....Pages 11-17 Dendritic Cells and Cytokines....Pages 19-23 Control of HIV Entry and Transcription, as a Possible Mechanism of the Antiviral Effects of T Lymphocytes in HIV Infection....Pages 25-31 Development of an Influenza-IscomTM Vaccine....Pages 33-49 Development of Parainfluenza Virus and Respiratory Syncytial Virus Subunit Vaccines....Pages 51-58 Mucosal Vaccines: Perspectives on the Development of Anti-H.pylori Vaccines....Pages 59-66 A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses....Pages 67-79 Induction of IL-12 Secretion and Enhanced Surface Expression of B7.1/B7.2 and ICAM-1 in Human Monocytes Activated by the Vaccine Carrier Brucella Abortus : Correlation with in Vivo Generation of Cellular Immune Responses....Pages 81-97 The Potential Use of Different Vaccination Protocols to Tailor Cytokine Profiles....Pages 99-109 Modulation of Cytokine Responses by Iscoms and Iscom-Matrix....Pages 111-118 Vaccines and Vaccine Delivery Systems: Experience with HSV, Influenza and Mucosal Routes of Immunisation....Pages 119-127 Active Immunotherapy for Solid Tumours....Pages 129-146 Iscoms as Mucosal Vaccine Vectors....Pages 147-153 Adjuvant Directed Immune Specificity at the Epitope Level: Implications for Vaccine Development a Model Study Using Semliki Forest Virus Infection of Mice....Pages 155-166 Interleukin 1 and Its Synthetic Peptide 163–171 as Vaccine Adjuvants....Pages 167-173 The Immunological Co-Adjuvant Action of Liposomal Interleukin-15....Pages 175-180 Protection Against Tuberculosis by Plasmid DNA....Pages 181-185 From Scientific Discovery to Clinical Trial: Overcoming the Regulatory Hurdles — A Guide for Academic Researchers....Pages 187-196 Back Matter....Pages 197-209 During the last decade or so vaccine development has been facilitated by rapid ad vances in the molecular and cell biology ofthe immune system. This has laid the foundations of a new generation of vaccines exemplified by subunit vaccines produced through gene cloning and by synthetic peptides mimicking small regions ofproteins on the outer coat ofvi ruses. However, as subunit and peptide vaccines are only weakly or non-immunogenic, there is areal need for strategies to improve their potency. This book contains the proceedings of the 5th NATO Advanced Studies Institute (ASI), "Vaccine Design: The Role of Cytokine Networks," held at Cape Sounion Beach, Greece, during 24 June-5 July 1996 and deals in depth with the role ofbasic immunology in the regulation of immunity and vaccine design. Special emphasis is given to the use of cyto kines in conjuction with vaccines with the aim ofimproving their potency or the use ofvac cines designed to improve cytokine production. We express our appreciation to Dr. J.-L. Virelizier and Dr. G. Kollias for their cooperation in planning the ASI and to Mrs. Concha Perring for her excellent production ofthe manuscripts. The ASI was held under the sponsor ship of NATO Scientific Affairs Division and generously co-sponsored by SmithKline Beecham Pharmaceuticals (Philadelphia). Financial assistance was also provided by Connaught Laboratories Ltd. (Ontario), Pasteur Merieux (Marcy I 'Etoile), Biochine (Siena), Help SA (Athens), and Avanti Polar Lipids Inc. (Birmingham, USA) ` This book should be very valuable to anyone interested in the basic design of vaccine strategies or the preclinical evaluation of novel vaccines and adjuvants. ' Doody's Journal ` I have little doubt that this book will become a standard reference for future development of vaccine formulations. ' European Journal of Pharmaceutics and Biopharmaceutics Vaccine Design. Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996