Use of high performance computing in meteorology : proceedings of the Twelfth ECMWF Workshop on the Use of High Performance Computing in Meteorology, Reading, UK, 30 October - 3 November 2006

Geosciences and, in particular, numerical weather prediction are demanding the highest levels of available computer power. The European Centre for Medium-Range Weather Forecasts, with its experience in using supercomputers in this field, organizes every other year a workshop bringing together manufacturers, computer scientists, researchers and operational users to share their experiences and to learn about the latest developments. This volume provides an excellent overview of the latest achievements and plans for the use of new parallel techniques in the fields of meteorology, climatology and oceanography. Adult or postnatal stem cells offer life-long cell replacement in tissues and organs, and are thus unavoidable targets of long-term and transient regenerative/epigenetic gene therapy for both inherited and acquired diseases; and effective anticancer therapy. In particular, autologous stem cells have been instrumental to the success of gene therapy, enabling breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders). This timely book highlights the pioneering translation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells to contribute to all three germ players. Pathologies are discussed in terms of stem cell repopulation dynamics, with appropriate niches (long-term engraftment) and tissues (cell turnover). Focus is also placed on the increasing number of identified tissue-specific cancer stem cells as the ultimate targets for recurrence-free cancer recovery, and on the development of armed stem cells as tumor-homing vectors for targeted anticancer stem cell gene therapy Geosciences particularly numerical weather predication, are demanding the highest levels of computer power available. The European Centre for Medium-Range Weather Forecasts, with its experience in using supercomputers in this field, organizes a workshop every other year bringing together manufacturers, computer scientists, researchers and operational users to share their experiences and to learn about the latest developments. This volume provides an excellent overview of the latest achievements and plans for the use of new parallel techniques in the fields of meteorology, climatology and oceanography.