Urinary tract

The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike Front Matter....Pages i-xii Overview on the Lower Urinary Tract....Pages 1-14 Animal Models in Overactive Bladder Research....Pages 15-43 Animal Models of Stress Urinary Incontinence....Pages 45-67 Animal Models for Benign Prostatic Hyperplasia....Pages 69-79 Use of Functional Imaging to Monitor Central Control of Voiding in Humans....Pages 81-97 Neuroanatomy of the Lower Urinary Tract....Pages 99-116 Anatomy and Histology of the Lower Urinary Tract....Pages 117-148 Neurophysiology of the Lower Urinary Tract....Pages 149-169 Afferent Mechanism in the Urinary Tract....Pages 171-205 Urothelial Signaling....Pages 207-231 Interstitial Cells of Cajal in the Urinary Tract....Pages 233-254 Potential Applications of Gene Therapy/Transfer to the Treatment of Lower Urinary Tract Diseases/Disorders....Pages 255-265 Specific Pharmacokinetic Aspects of the Urinary Tract....Pages 267-282 α 1 -Adrenoceptors in the Urinary Tract....Pages 283-306 β-Adrenergic Receptor Subtypes in the Urinary Tract....Pages 307-318 Muscarinic Acetylcholine Receptors in the Urinary Tract....Pages 319-344 Modulation of Urinary Bladder Innervation: TRPV1 and Botulinum Toxin A....Pages 345-374 Ion Channel Modulators and Urinary Tract Function....Pages 375-393 Neuropeptides in Lower Urinary Tract Function....Pages 395-423 Cannabinoids: Potential Targets for Bladder Dysfunction....Pages 425-451 Vasopressin Receptors in Voiding Dysfunction....Pages 453-483 ATP and P2X Purinoceptors in Urinary Tract Disorders....Pages 485-526 Cyclic Nucleotide Metabolism Including Nitric Oxide and Phosphodiesterase-Related Targets in the Lower Urinary Tract....Pages 527-542 Rho-Kinase, a Common Final Path of Various Contractile Bladder and Ureter Stimuli....Pages 543-568 Back Matter....Pages 569-577