Understanding craniofacial anomalies : the etiopathogenesis of craniosynostoses and facial clefting

"This comprehensive textbook, edited by world-renowned experts in the field, provides answers to challenges in the diagnosis and treatment of craniofacial anomalies.The book integrates basic science and clinical perspectives, creating a more unified and practical “patient centered” approach. Organized in a logical, easy-to-follow structure, this reference reviews and presents cutting-edge findings, covering the state of the art in craniosynostosis and facial clefting from molecular, genetic, cellular, tissue, organismic, and populations levels. Using standardized nomenclature and consistent terminology, Understanding Craniofacial Anomalies incorporates the recent explosion of growth in studying genetic and epigenetic etiologies of syndromes, thereby providing a unique and holistic review of this important topic." -- Publisher

UNDERSTANDING CRANIOFACIAL ANOMALIES

The Etiopathogenesis of Craniosynostoses and Facial Clefting

Mark P. Mooney and Michael I. Siegel

Craniofacial anomalies encompass a diversity of conditions that can primarily or secondarily affect the morphology and growth of either the head or face. Because patients may present both normal and abnormal tissues and organs, it is critical that clinicians are able to understand and relate the etiopathogenesis of craniofacial anomalies at the genetic, molecular, cellular, tissue, and organ levels to the prognosis and growth of the affected individual. Understanding Craniofacial Anomalies is an up-to-date guide to the etiology and pathogenesis of two of the most common craniofacial birth defects, craniosynostosis and facial clefting, for both the specialist and non-specialist. This novel volume:

* Provides answers to treatment challenges by integrating basic science and clinical points of view

* Presents cutting-edge basic science of value to laboratory scientists and accessible to clinicians with limited knowledge or training in the basic science aspects of this field

* Employs a logical, easy-to-follow organizational structure

* Uses standardized nomenclature and consistent terminology in order to provide an integrated review of the various classification systems

* Reflects the very recent explosion of growth in studying genetic and epigenetic etiologies of syndromes

* Gives a clear notion of the necessity and utility of animal modeling

* Offers future directions of research at both the molecular and clinical levels, with potential applications for both

Clinicians, residents, and basic scientists in craniofacial or plastic surgery, oral/maxillofacial surgery, dentistry, orthodontics, and otolaryngology, developmental biology, physical anthropology, and speech science will find Understanding Craniofacial Anomalies to be a vital addition to their professional libraries.

Doody Review Services

Reviewer:Rodrigue G. Barakat, DMD(Loyola University Medical Center)
Description:This is a unique reference and textbook in the area of craniofacial anomalies. It is a first of its kind.
Purpose:The purpose is to provide the reader with an understanding of two main enitites: craniosynostosis and facial clefting. It certainly achieves this goal while providing additional references.
Audience:This book targets a wide audience, from the unergraduate student to the graduate student. Multiple professionnals involved in the topic, molecular biologists, geneticists, craniofacial biologists, pathologists, specialists in growth and development, craniofacial surgeons, plastic surgeons, oral and maxillofacial surgeons, neurosurgeons, otolarynoglogists, dentists and speech and hearing pathologists.
Features:The book is divided into seven sections and 22 chapters. The sections cover classification and terminology, embryogenesis and etiology, animal modeling, cranial vault and cranial base dysmorphology and growth disturbances, mandibular and midfacial dysmorphology and growth disturbances, regional dysmorphology and growth disturbances, and, finally, molecular biology studies and future directions. Several perspectives are presented, including evolutionary, molecular, genetic, embryonic, growth and developemental, and dysmorphic.
Assessment:This book provides an excellent introduction to craniofacial anomalies. It provides a good mix of basic science and clinical aspects and reflects the recent explosion of growth in the knowledge about the study of genetics. This book takes different aspects of all the disciplines involved in craniofacial anomalies and puts it under one title.

This comprehensive textbook, edited by world-renowned experts in the field, provides answers to challenges in the diagnosis and treatment of craniofacial anomalies. The book integrates basic science and clinical perspectives, creating a more unified and practical patient centered approach. Organized in a logical, easy-to-follow structure, this reference reviews and presents cutting-edge findings, covering the state of the art in craniosynostosis and facial clefting from molecular, genetic, cellular, tissue, organismic, and populations levels. Using standardized nomenclature and consistent terminology, Understanding Craniofacial Anomalies incorporates the recentexplosion of growth in studying genetic and epigenetic etiologies of syndromes, thereby providing a unique and holistic review of this important topic As your knowledge and experience inj morphology (i.e., shape) and dymorphology (i.e., abnormal shape) increase, you will find yourself scrutinizing the craniofacial and somatic morphology of the people around you, noticing subtle and notso-subtle asymmetries, deviations, and abnormalities in everyone.