Unconjugated pterins and related biogenic amines : proceedings of the First International Workshop, Flims, Switzerland, february 28 - march 7, 1987

Die"Vorlesung über Moralphilosophie" aus den 1770er Jahren ist eine wichtige Erläuterung und Ergänzung zur "Grundlegung der Metaphysik der Sitten"von 1785. Die Neuedition der so genannten Menzer-Vorlesung präsentiert diese Vorlesung auf dem aktuellen Stand der Forschung. Zugrunde gelegt ist die Nachschrift Kaehler, die seit 1997 zum Kant-Archiv in Marburg gehört. Abgeglichen ist der Text mit mehreren Handschriften des Archivs der Berlin-Bandenburgischen Akademie der Wissenschaften und der Staatsbibliothek Berlin. Ein Anhang mit textkritischem Apparat und Erläuterungen zu Literatur und Personen sowie eine Einleitung von Manfred Kühn erschließen die Vorlesung für alle, die sich für die Kant'sche Philosophie der Ethik interessieren. In Memoriam: Alois Niederwieser (1935–1987) SECTION A: CHEMISTRY AND ANALYSIS OF PTERINS Homogeneous Catalytic Hydrogenation of L-Biopterin: Influence of the Chirality of the Side Chain and the Catalyst on its Diastereoselective Induction Synthesis of D-Neopterin-3'-Phosphates 5-Alkyl-5,6,7,8-Tetrahydrobiopterins Mass Spectrometric Investigations of Pteridines The Structural Characterization of 6-Pyruvoyl Tetrahydropterin by Fast Atom Bombardment Mass Spectrometry with One- and Two- Dimensional Mass Analysis (FAB/MS and FAB/MSMS) SECTION B: BIOCHEMISTRY AND METABOLISM OF PTERINS Tetrahydrobiopterin: Other Physiological Roles in Addition to Aromatic Amino Acid Hydroxylation? 1H-NMR Studies with Tetrahydrobiopterins, Evidence for the Structure of 6-Pyruvoyl Tetrahydropterin, an Intermediate in the Biosynthesis of Tetrahydrobiopterin Purification of 6-Pyruvoyl Tetrahydropterin Synthase from Salmon Liver Purification of 6-Pyruvoyl Tetrahydropterin 2'-Keto Reductase from Human Liver Human GTP Cyclohydrolase I: Purification and Preparation of Monoclonal Antibodies Dihydromonapterin Triphosphate: Occurrence, Analysis, and Effect on Tetrahydrobiopterin Biosynthesis in vivo and in vitro Biosynthesis of Pteridines and Deaza Flavins in Methanogenic Bacteria Tetrahydrobiopterin Biosynthesis and Pteridine Metabolism in Cells of the Blood System, Lymphoid Tissues and in Biological Fluids Modified Pteridine Synthesis in Transformed Cell Lines and during Heat Shock SECTION C: PTERINS IN IMMUNOLOGY Disease Associated Alterations of Pterin Biosynthesis: Enhancement in Inflammatory Disease, Hemopoietic Regeneration and Endotoxinemia Metabolism of Pterins in the Cellular Immune System of Man and Mouse Tetrahydrobiopterin Synthesis is Triggered by Interleukin 2 Binding and Modulates Receptor Affinity Kinetics of Production and Release of Neopterin. Comparison of Human PBMC with the Permanent Monocytic Cell Line U937 and its Subclones SECTION D: PTERINS IN DIFFERENT DISEASES Variations of Neopterin, Dihydroneopterin and Immunological Parameters during Physical Exercise (Jogging) Biopterin and Neopterin in Plasma and Lympho-Mononuclear Biopterin in Graft versus Host Disease and Infection after Bone Marrow Transplantation Effects of Pirenzepine, Aciclovir and Trimethoprim on Pterins in Blood Cells and Plasma SECTION E: TETRAHYDROBIOPTERIN DEFICIENCIES Heterogeneity of Tetrahydrobiopterin Deficiency Prenatal Diagnosis of Tetrahydrobiopterin Deficiency Sepiapterin Reductase in Human Amniocytes, Skin Fibroblasts, Chorionic Villi and Stimulated Mononuclear Blood Cells Impaired Biopterin Synthesis in a Patient with Mild Hyperphenylalaninemia. A New Variant? Dihydropteridine Reductase Activity in Fetal Tissues Molecular Analysis of Human Dihydropteridine Reductase and Dihydropteridine Reductase Deficiency Fate of Peripherally Administered Tetrahydrobiopterin in Congenital Tetrahydrobiopterin Deficiency 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency: Therapeutic Trial with Two Different Synthetic Pterin Analogues in Three Patients Placental Barrier in Mother-to-Fetus Transfer of Tetrahydrobiopterin in Humans SECTION F: MONOAMINE NEUROTRANSMITTERS AND ENZYMES Therapeutic Potential of Tetrahydrobiopterin Therapy in Neurological and Psychiatric Illness Organization of the Catalytic and Regulatory Sites of Rat Liver Phenylalanine Hydroxylase Immunochemical Studies of Phenylalanine Hydroxylase Influence of Substrates and Cofactors on Tyrosine Hydroxylase Mechanism of Activation of Tryptophan 5-Monooxygenase by Mercaptides Effects of Tetrahydropterins on DOPA Production in vitro and in vivo Pterins and Monoamine Metabolites in Cerebrospinal Fluid AUTHOR INDEX SUBJECT INDEX LIST OF PARTICIPANTS