Twenty Years of G-CSF: Clinical and Nonclinical Discoveries (Milestones in Drug Therapy)

Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This __Milestones in Drug Therapy__ volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF. Front Matter....Pages i-xxii Front Matter....Pages 1-1 Hematopoiesis in 2010....Pages 3-13 Discovery of G-CSF and Early Clinical Studies....Pages 15-24 Mouse Models of G-CSF Signaling in Hematopoiesis....Pages 25-40 The Clinical Pharmacology of Filgrastim and Pegfilgrastim....Pages 41-60 Structural Biology of G-CSF and Its Receptor....Pages 61-82 G-CSF Receptor Structure, Function, and Intracellular Signal Transduction....Pages 83-105 Front Matter....Pages 107-107 Practice Guidelines for the Use of rHuG-CSF in an Oncology Setting....Pages 109-149 Use of r-metHuG-CSF to Enable Chemotherapy Delivery for Solid Tumors....Pages 151-168 Use of rHuG-CSF for the Treatment of Myeloid Leukemia and in Targeting Leukemia Stem Cells....Pages 169-182 Use of rHuG-CSF in Myelodysplastic Syndromes....Pages 183-193 The Role of Hematopoietic Growth Factors in Aplastic Anemia: An Evidence-Based Perspective....Pages 195-210 Using rHuG-CSF in Multiple Myeloma: Consolidated Data, Evolutions, and New Concepts....Pages 211-223 Use of rHuG-CSF in New Chemotherapy Strategies....Pages 225-247 rHuG-CSF in Peripheral Blood Progenitor Cell Transplantation....Pages 249-275 Front Matter....Pages 277-277 rHuG-CSF for the Treatment of Severe Chronic Neutropenia....Pages 279-291 Investigational Studies of rHuG-CSF to Promote the Regeneration of Nonhematopoietic Tissues....Pages 293-317 Use of rHuG-CSF in Infectious Diseases....Pages 319-333 Use of Filgrastim (r-metHuG-CSF) in Human Immunodeficiency Virus Infection....Pages 335-363 Recombinant Human G-CSF Enhances Recovery and Improves Survival from Severe Radiation-Induced Myelosuppression....Pages 365-380 Neutropenias in Felty’s Syndrome and Systemic Lupus Erythematosus....Pages 381-391 Front Matter....Pages 393-393 The Safety Profile of Filgrastim and Pegfilgrastim....Pages 395-408 Economics of the Recombinant Human Granulocyte Colony-Stimulating Factors....Pages 409-420 Front Matter....Pages 421-421 Role of Myeloid Cells in Tumor Angiogenesis....Pages 423-433 G-CSF-Induced Mobilization of Bone Marrow Stem Cells and Cardiac Repair....Pages 435-462 Erratum to: The Role of Hematopoietic Growth Factors in Aplastic Anemia: An Evidence-Based Perspective....Pages E1-E4 Back Matter....Pages 463-471