Tutorials in Mathematical Biosciences II: Mathematical Modeling of Calcium Dynamics and Signal Transduction (Lecture Notes in Mathematics / Mathematical Biosciences Subseries)

This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, this book also presents much of the underlying physiology, so that readers may learn both the mathematics and the physiology at the same time, and see how the models are applied to specific biological questions. It is thus neither a mathematics book nor a physiology book, but has features from both sides of the fence. It is intended primarily as a graduate text or a research reference. However, some parts of the book, particularly the introductory chapters on calcium dynamics will be well within the reach of some undergraduates. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.

This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions.

It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.

Basic Concepts of Ca 2+ Signaling in Cells and Tissues....Pages 1-13 Modeling IP 3 -Dependent Calcium Dynamics in Non-Excitable Cells....Pages 15-61 Integrated Calcium Management in Cardiac Myocytes....Pages 63-95 Mechanisms and Models of Cardiac Excitation-Contraction Coupling....Pages 97-131 Mathematical Analysis of the Generation of Force and Motion in Contracting Muscle....Pages 133-153 Signal Transduction in Vertebrate Olfactory Receptor Cells....Pages 155-171 Mathematical Models of Synaptic Transmission and Short-Term Plasticity....Pages 173-202 The only classroom-based training and self-assessment system! Osborne's Sun Certified System Administrator for Solaris 8 Study Guide provides 100% complete coverage of all official exam objectives for both exams. Based on 200,000+ hours of IT training experience, the book contains hundreds of practice exam questions and hands-on exercises. The CD-ROM features full CertTrainer CBT software with interactive tutorials and lab simulations, plus the new ExamSim adaptive test engine. With this guide, the only one that covers this newly updated certification, candidates can skip expensive three-week training program and study at their own pace for exams 310-009 and 310-010. The CD includes Test Yourself Testing Center for both exams and the electronic version of the book. Living tissues are complex organizations of individual cells and to perform their specific functions the activity of each cell within the tissue must be regulated in a coordinated manner.