Tumors of the Central Nervous System, Volume 14 : Glioma, Meningioma, Neuroblastoma, and Spinal Tumors

This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors. Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery. This handbook, as earlier volumes in the series, will appeal to professionals involved in the treatment of cancer, as well as to researchers. The series crosses subjects of diagnosis, drug development, therapy and its assessment and prognosis of tumors of the central nervous system, cancer recurrence and resistance to chemotherapy. Front Matter....Pages i-xxxviii Angiocentric Glioma, Pilomyxoid Astrocytoma, and Pituicytoma: New Entities in the World Health Organization Classification....Pages 1-11 Pediatric Low-Grade Gliomas: Diagnosis, Treatment, and Future Directions....Pages 13-24 Kringle 1-5 Reduces Growth of Malignant Gliomas in Rats....Pages 25-34 Fluorescence Guided Resection and Photodynamic Therapy in Meningiomas....Pages 35-41 Classification of Meningiomas in the Cerebellopontine Angle....Pages 43-53 Postoperative Cerebral Hyperemia—Pathophysiology and Clinical Concerns....Pages 55-66 Evidence-Based Approach for the Management of Cerebral Metastases from Lung Adenocarcinoma....Pages 67-77 Intramedullary Spinal Cord Tumors: Long-Term Follow-Up After Surgery....Pages 79-93 Back Matter....Pages 95-98 Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade