Tumor virus-host cell interaction : [lectures presented at the 1973 NATO Advanced Study Institute on Tumor Virus-Host Cell Interaction, held in Monte Carlo, Monaco, September 1973

The oncogenic virus can only be studied as a carcinogen when its relation to the host cell in which it resides is understood. The interaction between tumor virus and host cell was the subject of a recent North Atlantic Treaty Organization Advanced Study I~stitute. This volume is the edited proceedings of this study institute. One problem of fundamental importance in understanding malignant transformation is the mechanism by which the oncogenic vector promotes the aberrations in the host cell regulatory appara­ tus resulting in a cancerous cell. It is partly the purpose of this volume to help clarify this problem, and to stimulate the interest of others to continue the research necessary to this end. The meeting from which this volume is compiled took place in the Principality of Monaco with the patronage of Her Serene High­ ness, Princess Grace and was supported principally by a grant from the North Atlantic Treaty Organization. The editor wishes to thank the North Atlantic Treaty Organization, Princess Grace of Monaco, and the Bureau de Tourism Monaco for their generous support. Addi­ tional financial assistance was provided by the Deutsches Studium Gesellschaft and I would like to thank Prof. Klaus Munk, Deutsches Krebsforschungszentrum, for his help in obtaining this aid. I would also like to thank the Verwaltung of the Deutsches Krebsfor­ schungszentrum for their administrative help. Front Matter....Pages i-x Front Matter....Pages 1-1 Knowledge and Ignorance about the Molecular Biology of Small Oncogenic DNA Containing Viruses....Pages 3-11 Studies of SV40 DNA Replication....Pages 13-19 An Analysis of the Structure of the Replicating Fork During Discontinuous Synthesis of SV40 DNA and the Detection of Gap Circle Intermediates....Pages 21-37 The Repeated Sequences in Serially Passaged SV40 DNA....Pages 39-58 Some Properties of Superhelical Oligomeric and Integrated SV40 DNA Sequences....Pages 59-67 Simian Virus 40 in Synchronized Monkey Cells: Integration of Viral DNA into the Cell Genome and Timing of Replication....Pages 69-89 Transcription of SV40 in Lytically Infected and Transformed Cells....Pages 91-116 The Structural Proteins of SV40 and Polyoma Virus....Pages 117-125 The Cell Free Translation of Purified Simian Virus 40 Messenger RNA....Pages 127-139 Studies on Non-Transforming Host Range Mutants of Polyoma Virus....Pages 141-147 The Properties of a Polyoma Virus Mutant, ts 3 ....Pages 149-151 Front Matter....Pages 153-153 Intracellular forms of Adenovirus DNA in Productively Infected Cells: Evidence for Integration of the Viral Genome....Pages 155-181 The Mechanism of Replication of Adenovirus Type 5 DNA....Pages 183-195 The Isolation and Characterization of DNA Binding Proteins Specific for Adenovirus Infected Cells....Pages 197-216 Adenovirus DNA: Transcription During Productive Infection, Integration in Transformed Cells, and Replication in Vitro ....Pages 217-236 Characterization and Metabolism of Nuclear Viral RNA Synthesized 18 Hours after Infection with Adenovirus 2....Pages 237-252 Front Matter....Pages 253-253 The Provirus of Rous Sarcoma Virus: Synthesis, Integration and Transcription....Pages 255-265 Temperature-Sensitive DNA Polymerase from Rous Sarcoma Virus Mutants....Pages 267-272 Mechanism of Inhibition of RNA Tumor Virus Reverse Transcriptase by Rifamycin SV Derivatives....Pages 273-291 Cell Surface Antigens in Oncornavirus Transformed Cells....Pages 293-302 Front Matter....Pages 253-253 Stability of Avian Oncornavirus Precursor Protein in a Line of Rsv-transformed Hamster Cells....Pages 303-310 Comparative Studies on the Molecular Basis for a Viral Involvement in Murine and Human Mammary Adenocarcinoma....Pages 311-330 Use of Pseudotypes of Vesicular Stomatitis Virus to Study Cellular Resistance to Murine Rna Tumor Viruses....Pages 331-336 Human Acute Leukemia: Increasing Evidence for Involvement of Type-C Rna Tumor Viruses....Pages 337-352 Front Matter....Pages 353-353 Herpes Simplex Virus: Aspects of Structure and Regulation of Viral Rna and Protein Synthesis....Pages 355-395 Malignant Transformation by Herpesviruses....Pages 397-414 Recognition of Virus Genomes in Cells by Molecular Hybridization....Pages 415-425 The Characterization of an in Vitro Isolated Nuclei System for the Investigation of the Mechanism of Herpesvirus DNA Replication in Infected Human Embryonic Lung Cells....Pages 427-443 Back Matter....Pages 445-461