Tumor Cell Differentiation: Biology and Pharmacology (Experimental Biology and Medicine, 17)

This volume contains the proceedings of an International Symposium on the Biology and Pharmacology of Tumor Cell Differentiationheld on June 29-July I, 1986 at the University of Tromso, Norway. The objective of this meeting was to bring together scientists from various disciplines to discuss recent advances in the understanding of tumor cell differentiation and to bridge the gap between experimental findings and clinical application of new knowledge. Thus the information will be of value not only to basic scientists involved in molecular and cell biology, but also to pharmacologists and clinicians trying to develop the concept of tumor cell differentiation as a therapeutic modality. Each plenary speaker and selected poster presenters were requested to submit a comprehensive, up-to-date review of recent contributions to their disciplines related to differentiation and: hematopoietic factors and leukemic cells in culture~ vitamin derivatives and polyamines; nucleosides and methylation; and cell interactions. Front Matter....Pages i-xv Front Matter....Pages 1-1 Hematopoietic Growth and Differentiation Factors and the Reversal of Malignancy....Pages 3-27 G-CSF as a Differentiation-Inducing Agent in Normal and Leukemic Myelopoiesis....Pages 29-49 Induction of Differentiation in Myeloid Leukemic Cells and the Differentiation Inducing Factor (DIF)....Pages 51-59 Proliferation and Differentiation of Human Leukemic Cells in Culture....Pages 61-69 Infrequent Phenotypes of Clonogenic Cells in AML: Evidence for Abnormal Differentiation and Possibilities for Detecting Minimal Disease?....Pages 71-78 Studies of Gene Expression During Granulocyte Maturation....Pages 79-103 Granulocytes Obtained from HL-60 Cells by Retinoic Acid Treatment Behave Abnormally in Hematopoietic Regulation — Possible Consequences for Differentiation Induction Treatment of Leukemia....Pages 105-113 Beta -Adrenergic Receptors of Normal, Transformed and Immature Human Leucocytes....Pages 115-120 Front Matter....Pages 121-121 Molecular and Cellular Aspects of Embryonal Carcinoma Cell Differentiation....Pages 123-136 Interaction of 1,25 Dihydroxyvitamin D 3 with Normal and Abnormal Hematopoiesis....Pages 137-157 Retinoic Acid-Induced Differentiation of HL-60: Studies in Vitro and in Vivo....Pages 159-181 Plasma Membrane Signals Linked to the Retinoic Acid-Induced Differentiation of HL-60 Cells....Pages 183-194 Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?....Pages 195-203 Therapeutic Effects of Low-Dose Cytosine Arabinoside, α-Interferon, 1,25-Dihydroxyvitamin D 3 and Retinoic Acid in Myelodysplastic Syndromes and Acute Leukemia....Pages 205-212 Front Matter....Pages 213-213 Sequence-Specific DNA Methylation: Promoter Inactivation and Release of the Expression Block....Pages 215-230 Induction of Differentiation of 3T3-L1 Fibroblasts to Adipocytes by 3-Deazaadenosine and Insulin....Pages 231-240 Differentiation of Human Leukemia Cells by Nucleoside Analogues....Pages 241-249 Effects of Purine Nucleosides on Differentiation in Lymphohematopoietic Stem Cell Leukemia....Pages 251-258 Effect of Methylation Inhibitors on Phorbol Ester Induced Differentiation of HL-60 Promyelocytic Leukemia Cells....Pages 259-267 Perturbation of Homocysteine Metabolism by Pharmacological Agents in Experimental and Clinical Use....Pages 269-278 Front Matter....Pages 213-213 C-8-Substituted Guanosine Analogues are Novel Immunostimulants and Differentiating Agents for Neonatal, Normal and X-Linked Immune Defective ( xid ) B Lymphocytes....Pages 279-287 Front Matter....Pages 289-289 Differentiation as a Mechanism for Control of Malignancy in Human Cell Hybrids....Pages 291-304 Interaction Between Brain Tissue and Malignant Glioma Cells in Organ Culture....Pages 305-315 Tumor Promoter-Mediated Modulation of Cell Differentiation and Communication: The Phorbol Ester — Oncogene Connection....Pages 317-339 Back Matter....Pages 341-347