Tumor Antigens Recognized by T Cells and Antibodies (Tumorimmunology and Immunotherapy Series, 1)

Hammersmith Hospital, London, UK. Text provides a comprehensive overview of the molecular nature of tumor antigens recognized by antibodies, helper T lymphocytes, and cytotoxic T lymphocytes. Provides the basis for improved immunotherapy in cancer treatment. For clinicians and researchers. DNLM: Antigens, Neoplasm. Book Cover......Page 1 Title......Page 4 Contents......Page 5 List of figures......Page 8 List of tables......Page 10 List of contributors......Page 12 Series preface......Page 16 Preface......Page 18 Animal models......Page 20 Mouse models in the recognition of tumor antigens......Page 22 Role of heat shock protein in chaperoning tumor antigens and modulating anti-tumor immunity......Page 39 Human tumor antigens recognized by class I HLA-restricted T cells......Page 54 WT1 as target for tumor immunotherapy......Page 56 Human melanoma antigens recognized by CD8+ T cells......Page 66 Squamous cell and adeno cancer antigens recognized by cytotoxic T lymphocytes......Page 94 Altered peptide ligands of tumor T-cell epitopes: implications for more effective vaccine therapy in human neoplasia......Page 116 Ex vivo and in situ detection of tumor-specific T-cell immunity with MHC tetramers......Page 130 Human tumor antigens recognized by class II HLA-restricted T cells......Page 150 Antigens of the MAGE family recognized by CD4+ T cells......Page 152 Melanoma antigens recognized by CD4+ T cells......Page 160 Human tumor antigens recognized by antibodies......Page 178 Human tumor antigens recognized by antibodies (SEREX)......Page 180 Antibodies to human tumor oncoproteins in cancer patients......Page 191 Antibody and T-cell responses to the NY-ESO-1 antigen......Page 210 Index......Page 218

recent Progress In Fundamental Tumor Immunology Has Led To Immunotherapy Trials In Patients With Solid Tumors And Hematological Malignancies. In The Past, Immunotherapy Approaches Were Primarily Based On Enhancement Of Tumor Immunity With Cytokines And Adjuvant Therapy, Without Knowledge Of Relevant Tumor Antigens. The Discovery Of Tumor Antigens Capable Of Eliciting Immune Responses Has Now Resulted In The Development Of Antigen-specific Immunotherapy Strategies. Vaccination With Defined Peptide Epitopes, Purified Proteins, Cell Components, And Whole Cells Expressing Defined Tumor Antigens Provides An Opportunity To Measure Antigen-specific Immune Responses In Vaccinated Patients, And To Correlate Immunity With Clinical Outcome.

tumor Antigens Recognized By T Cells And Antibodies Provides A Comprehensive Overview Of The Molecular Nature Of Tumor Antigens That Can Be Recognized By Antibodies, Helper T Lymphocytes And Cytotoxic T Lymphocytes. Novel Strategies To Enhance Ineffective Immunity Against Such Antigens Provide The Basis For Improved Immunotherapy Protocols For Patient Treatment. With Contributions From A Host Of International Experts In The Field, This Book Provides Invaluable Information For Clinicians And Researchers With An Interest In Cancer Immunotherapy.

Mouse models in the recognition of tumour antigens / Vito R. Cicinnati, Susanne Beckebaum and Albert B. Deleo Role of heat shock protein in chaperoning tumor antigens and modulating anti-tumor immunity / Zihai Li WT1 as target for tumor immunotherapy / Hans J. Stauss ... [et al.] Human melanoma antigens recognized by CD8+ T cells / Yutaka Kawakami Squamous cell and adeno cancer antigens recognized by cytotoxic T lymphocytes / Kyogo Itoh ... [et al.] Altered peptide ligands of tumor T-cell epitopes: implications for more effective vaccine therapy in human neoplasia / Licia Rivoltini ... [et al.] Ex vivo and in situ detection of tumor-specific T-cell immunity with MHC tetramers / Ton N.M. Schumacher and John B.A.G. Haanen Antigens of the MAGE family recognized by CD4+ T cells / Catia Traversari Melanoma antigens recognized by CD4+ T cells / Rong-Fu Wang Human tumor antigens recognized by antibodies (SEREX) / Michael Pfreundschuh ... [et al.] Antibodies to human tumor oncoproteins in cancer patients Lupe Salazar and Mary L. Disis Antibody and T-cell responses to the NY-ESO-1 antigen / Elke Jäger, Dirk Jäger and Alexander Knuth. Mouse models in the recognition of tumour antigens / Vito R. Cicinnati, Susanne Beckebaum and Albert B. Deleo The Wilms tumour antigen as CTL target / Hans J. Stauss Heat/shock proteins and tumour antigens / Zihai Li Melanoma antigens recognized by CD8+ T cells / Yutaka Kawakami Squamous cells and adeno cancer antigens recognized by T cells / Kyogo Itoh ... [et al.] Altered peptide ligands of tumor T cell epitopes: implications for more effective vaccine-therapy in human neoplasia / Licia Rivoltini Ex vivo and in situ tetramer analysis of CTL responses to tumours / Ton N. Schumacher and John B.A.G. Haanen Antigens of the mage family recognized by CD4+ T cells / Catia Traversari Melanoma antigens recognized by CD4+ T cells / Rongfu Wang Human tumour antigens recognized by antibodies (serex) / Michael Pfreundschuh ... [et al.] Antibodies to tumour oncoproteins in cancer patients Lupe Salazar and Mary L. Disis Antibody and CTL responses to the NY-ESO antigen / Elke Jäger, Dirk Jäger and Alexander Knuth. Accompanying the clinical introduction of tumor vaccines has been an increasing awareness for the need of suitable preclinical mouse tumor model systems to guide some of the potentially critical analogous issues and concerns that arise in the design and implementation of clinical protocols.