Trophoblast Invasion And Endometrial Receptivity: Novel Aspects Of The Cell Biology Of Embryo Implantation (trophoblast Research) (volume 4)

Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, older data can be reevaluated in the light of current research into cell­ cell and cell-matrix interactions. The feeling that new avenues of research are open was apparent when an international group of scientists came together at a workshop on "The Cell Biology of Trophoblast Invasion In Vivo and In Vitro" held during the XXIV Annual Meeting of the Cell, Tissue and Organ Culture Study Group (C.T.O.C.) at Heidelberg in 1986. What was unusual about this Conference was the interdisciplinary dialogue between implantation researchers and tumor biologists, highlighting aspects common to invasion of trophoblast and tumor cells. Front Matter....Pages i-xi Front Matter....Pages 1-1 Trophoblast - Endometrial Interactions at Embryo Implantation: A Cell Biological Paradox....Pages 3-29 Front Matter....Pages 31-31 Trophoblast Invasion and Placentation in the Human: Morphological Aspects....Pages 33-47 Front Matter....Pages 49-49 An In Vitro Model for Studying Interactions Between Mouse Trophoblast and Uterine Epithelial Cells....Pages 51-69 A Three-Dimensional Organ Culture Model for the Study of Implantation of Rabbit Blastocyst In Vitro....Pages 71-95 Choriocarcinoma Cell Spheroids: An In Vitro Model for the Human Trophoblast....Pages 97-111 Front Matter....Pages 113-113 Adhesive Interactions of Murine and Human Trophoblast Cells....Pages 115-138 The Role of Matrix Macromolecules in the Invasion of Decidua by Trophoblast: Model Studies Using BeWo Cells....Pages 139-158 Interactions Between the Human Trophoblast Cells and the Extracellular Matrix of the Endometrium. Specific Expression of α-Galactose Residues by Invasive Human Trophoblastic Cells....Pages 159-177 Appearance, Shedding and Endocytosis of a Blastocyst Surface Galactose-Galactosamine Derivate Detected with a Monoclonal Antibody....Pages 179-189 Antigenic Expression by Migrating Trophoblast and its Relevance to Implantation....Pages 191-207 Front Matter....Pages 209-209 Glycoconjugate Expression and Interactions at the Cell Surface of Mouse Uterine Epithelial Cells and Periimplantation-Stage Embryo....Pages 211-241 Uterine Receptivity to Implantation in the Rabbit: Evidence for a 42 kDa Glycoprotein as a Marker of Receptivity....Pages 243-258 Possible Involvement of D-Galactose in the Implantation Process....Pages 259-272 Histochemical Characteristics of the Endometrial Surface Related Temporally to Implantation in the Non-Human Primate (Macaca fascicularis)....Pages 273-284 Changes in Lectin Binding Patterns in Rabbit Endometrium During Pseudopregnancy, Early Pregnancy and Implantation....Pages 285-305 Preparation of Rabbit Uterine Epithelium for Trophoblast Attachment: Histochemical Changes in the Apical and Lateral Membrane Compartment....Pages 307-322 Changes in Lipid Organization of Uterine Epithelial Cell Membranes at Implantation in the Rabbit....Pages 323-338 Cell Surface Components of Human Endometrial Epithelium: Monoclonal Antibody Studies....Pages 339-356 Changes of Intermediate Filament Protein Localization in Endometrial Cells During Early Pregnancy of Rabbits....Pages 357-374 Front Matter....Pages 375-375 Biochemical and Structural Changes in Uterine Endometrial Cell Types Following Natural or Artificial Deciduogenic Stimuli....Pages 377-416 Front Matter....Pages 375-375 Penetration of the Basal Lamina by Processes of the Uterine Epithelial Cells during Implantation in the Rabbit....Pages 417-430 Endometrial Leukocytes in Human Pregnancy....Pages 431-451 Back Matter....Pages 453-462