Treatments of neurodevelopmental disorders : targeting neurobiological mechanisms

This cutting-edge book brings advances in genetics, neurobiology, and psychopharmacology to the clinic to enhance treatment for neurodevelopmental disorders. Significant progress has been made in identifying the neurobiological mechanisms of several disorders and targeted treatments are modifying the outcome of these disorders. However, the ability to utilize this knowledge has not been summarized in one place for the practicing clinician. This book will fill that gap by providing the theoretical underpinnings and the latest advances in targeted treatments. Several neurodevelopmental disorders are reviewed in detail including clinical features and behavioral phenotypes, standard treatments and new targeted treatments based on the latest advances in neurobiology and the animal model studies that have led to new treatments. The disorders covered include psychiatric disorders: schizophrenia, depression, autism and ADHD; single gene disorders including Tuberous Sclerosis, Fragile X Syndrome and fragile X- associated disorders, Angelman Syndrome, PKU, and Muscular Dystrophies; and complex genetic disorders such as Down syndrome. This book also highlights the commonalities across disorders and new genetic and molecular concepts in an easy to read format. This is a very exciting time for new targeted treatments and this volume is a landmark treatise on this new age of treatment. Overview Of Neurodevelopmental Processes And The Assessment Of Patients With Neurodevelopmental Disorders / Robert Hendren, Andre Goldani, Randi Hagerman -- Autism : Neurobiologic Mechanisms And Targeted Treatments / Robert Hendren And Randi Hagerman -- Targeted Treatments In Schizophrenia / Danielle A. Schlosser, Coleman Garrett, Sophia Vinogradov -- Neurodevelopmental And Neurobiological Aspects Of Major Depressive Disorder : From Theory To Therapy / Blake Rawdin, Daniel Lindqvist, Nicole Bush, Steven Hamilton, Ruhel Boparai, Scott Mackin, Victor I. Reus, Synthia H. Mellon, Owen M. Wolkowitz -- Attention Deficit Hyperactivity Disorder / Kyle J. Rutledge, Khyati Brahmbhatt, Julie Schweitzer -- Targeted Treatments In Rett Syndrome / Daniel C. Tarquinio, Walter E. Kaufmann -- Cardio-facio-cutaneous Syndrome And Other Rasopathies : Prospects For Treatment / William E. Tidyman And Katherine A. Rauen -- Targeted Treatments In Tuberous Sclerosis Complex (tsc) / Petrus J. De Vries -- Treatment Of Fragile X Syndrome And Fragile X-associated Disorders / Reymundo Lozano, Emma B. Hare, Randi J. Hagerman -- Angelman Syndrome / Mary Jacena Leigh, Lindsey Partington, Edwin Weeber -- Pharmacotherapy For Cognitive Enhancement In Down Syndrome / Aarti Ruparelia, David Patterson, William C. Mobley -- Targeted Treatments For Phenylketonuria / Billur Moghaddam -- Muscular Dystrophies : Diagnosis And New Treatments / Bethany M. Lipa, Que T. Nguyen, Jay J. Han -- Translating Treatments From The Laboratory To The Clinic / Randi Hagerman, Billur Mogahadam, Jan Nolta, Maria Diez, Robert Hendren. Edited By Randi Jenssen Hagerman, Md, Distinguished Professor Of Pediatrics, Endowed Chair In Fragile X Research, Medical Director Of The Mind Institute, Sacramento, California, And Robert L. Hendren, Do, Professor And Vice-chair, Director, Child And Adolescent Psychiatry, University Of California, San Francisco, San Francisco, California. Includes Bibliographical References.