Transplantation antigens; markers of biological individuality, (Immunology: an international series of monographs and treatises)

Transplantation Antigens: Markers of Biological Individuality investigates transplantation antigens and their function as markers of biological individuality. Topics covered include transplantation antigens of the human fetus, trophoblast, and spermatozoa; tissue distribution and cellular location of transplantation antigens; and serologic identification of human transplantation antigens. The biological significance of cross-reactions between histocompatibility antigens and antigens of bacterial and/or heterologous mammalian origin is also examined. This book is comprised of 25 chapters and begins with an introduction to the phylogeny of transplantation reactivity, followed by a discussion on the appearance of transplantation antigens in the embryo and fetus and the ways in which these antigens interact with or are masked from the immunocytes of the pregnant female. The next chapter analyzes the data on the detection of transplantation antigens on human fetal cells, cells of trophoblastic origin, and spermatozoa. The intracellular distribution of transplantation antigens is also considered, along with the extraction of membranous transplantation antigens by pressure homogenization; the molecular nature of HL-A antigens; and solubilization of histocompatibility antigens with detergents. This monograph will appeal to biologists, physiologists, immunologists, and clinicians. Content: IMMUNOLOGY: An International Series of Monographs and Treatises , Page ii Front Matter , Page iii Copyright , Page iv Dedication , Page v LIST OF CONTRIBUTORS , Pages xv-xvi FOREWORD , Pages xvii-xx , P.B. Medawar INTRODUCTION , Pages xxi-xxv , Barry D. Kahan, Ralph A. Reisfeld CHAPTER 1 - PHYLOGENY OF TRANSPLANTATION REACTIVITY , Pages 3-73 , W.H. HILDEMANN CHAPTER 2 - HISTOCOMPATIBILITY GENES, TRANSPLANTATION ANTIGENS, AND PREGNANCY , Pages 75-114 , MICHAEL EDIDIN CHAPTER 3 - TRANSPLANTATION ANTIGENS OF THE HUMAN FETUS, TROPHOBLAST, AND SPERMATOZOA , Pages 115-123 , H.F. SEIGLER, R.S. METZGAR CHAPTER 4 - THE TISSUE DISTRIBUTION AND CELLULAR LOCATION OF TRANSPLANTATION ANTIGENS , Pages 125-140 , MICHAEL EDIDIN CHAPTER 5 - INTRACELLULAR DISTRIBUTION OF TRANSPLANTATION ANTIGENS , Pages 141-148 , LIONEL A. MANSON, JOY PALM CHAPTER 6 - SEROLOGIC IDENTIFICATION OF HUMAN TRANSPLANTATION ANTIGENS: THE HL-A SYSTEM , Pages 149-179 , F. KISSMEYER-NIELSEN CHAPTER 7 - THE BIOLOGICAL SIGNIFICANCE OF CROSS-REACTIONS BETWEEN HISTOCOMPATIBILITY ANTIGENS AND ANTIGENS OF BACTERIAL AND/OR HETEROLOGOUS MAMMALIAN ORIGIN , Pages 181-208 , FELIX T. RAPAPORT CHAPTER 8 - SPECIES-DISTRIBUTION AND EVOLUTIONARY DEVELOPMENT OF HL-A ANTIGENS , Pages 209-224 , R.S. METZGAR, H.F. SEIGLER CHAPTER 9 - EXTRACTION OF MEMBRANOUS TRANSPLANTATION ANTIGENS BY PRESSURE HOMOGENIZATION , Pages 227-235 , LIONEL A. MANSON CHAPTER 10 - THE SONIC PROCESS FOR SOLUBLE ANTIGEN PREPARATION , Pages 237-258 , BARRY D. KAHAN CHAPTER 11 - SALT EXTRACTION OF SOLUBLE HL-A ANTIGENS , Pages 259-272 , R.A. REISFELD, M.A. PELLEGRINO CHAPTER 12 - PURIFICATION AND STRUCTURAL STUDIES OF ALLOANTIGEN DETERMINANTS SOLUBILIZED WITH PAPAIN , Pages 273-286 , ARNOLD R. SANDERSON, KEN I. WELSH CHAPTER 13 - COMPARISONS OF HL-A ALLOANTIGENS SOLUBILIZED BY PAPAIN AND TIS , Pages 287-297 , DEAN L. MANN CHAPTER 14 - SOLUBILIZATION OF HISTOCOMPATIBILITY ANTIGENS WITH DETERGENTS , Pages 299-308 , RICHARD S. METZGAR, JUNE L. MILLER, H.F. SEIGLER CHAPTER 15 - THE IN VIVO IMMUNOGENICITY ASSAY OF TRANSPLANTATION ANTIGENS , Pages 311-338 , BARRY D. KAHAN CHAPTER 16 - THE INDUCTION OF ALLOGRAFT IMMUNITY IN VITRO , Pages 339-356 , LIONEL A. MANSON, TOBIANNE SIMMONS CHAPTER 17 - WHEREFORE THE MIXED LEUKOCYTE REACTION , Pages 357-382 , JOOST J. OPPENHEIM CHAPTER 18 - THE ENHANCEMENT ASSAY FOR PROLONGATION OF GRAFT SURVIVAL , Pages 383-390 , A.A. KANDUTSCH CHAPTER 19 - PROLONGATION OF GRAFT SURVIVAL BY ADMINISTRATION OF WATER-SOLUBLE ANTIGENS , Pages 391-409 , RICHARD E. WILSON CHAPTER 20 - DELAYED-TYPE HYPERSENSITIVITY ASSAYS IN THE DETECTION AND BIOLOGICAL CHARACTERIZATION OF TRANSPLANTATION ANTIGENS , Pages 411-432 , BARRY D. KAHAN CHAPTER 21 - SEROLOGIC DETECTION OF SOLUBLE HL-A ANTIGENS , Pages 433-452 , M.A. PELLEGRINO, S. FERRONE, A. PELLEGRINO CHAPTER 22 - THE STUDY OF ISOIMMUNE ANTIBODIES AND ANTIGENIC DETERMINANTS USING THE 51 CHROMIUM CYTOTOXIC ASSAY , Pages 453-473 , ARNOLD R. SANDERSON, KEN I. WELSH CHAPTER 23 - PERSPECTIVES ON THE ROLE OF HL-A ANTIGENS , Pages 477-488 , BARRY D. KAHAN CHAPTER 24 - THE MOLECULAR NATURE OF HL-A ANTIGENS , Pages 489-502 , R.A. REISFELD, B.D. KAHAN CHAPTER 25 - PROSPECTUS: FUTURE ADVENTURES IN TRANSPLANTATION ANTIGEN RESEARCH , Pages 503-507 , G.J.V. NOSSAL Author Index , Pages 509-531 Subject Index , Pages 533-538