Transplantation and Changing Management of Organ Failure : Proceedings of the 32nd International Conference on Transplantation and Changing Management of Organ Failure, 25–26 May, 2000

This book, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. Some promising treatments are approached, such as enzymic and biochemical replacement, gene therapy, tolerance induction, stem cell transplantation, and xenotransplantation. In addition to the constant improvement in conservative management of organ failure in general, ongoing research in selected fields is reported in the proceedings, such as liver transplantation __vs__ artificial liver, novel dialysis strategies __vs__ evolving immunosuppression in kidney transplantation, islets transplantation and external implantable insulin pumps __vs__ pancreas transplantation in diabetic patients, circulatory assistance and intramyocardial myoblast injection __vs__ heart transplantation. Pivotal experience in selected emerging transplantations is included, that is, small bowel, limb, skin and neuronal transplantation. Such fascinating perspectives raise medical, economical, and ethical problems which are discussed in this book. Front Matter....Pages i-ix Front Matter....Pages 1-1 Trends in the epidemiology of end-stage renal disease over the last decade....Pages 3-28 Answers to liver graft shortage: hepatocyte transplantation and bioartificial liver....Pages 29-37 Enzymatic and biochemical substitutes to organ transplantation in inborn errors of metabolism....Pages 39-45 Tolerance induction....Pages 47-55 Xenotransplantation: immunological advances....Pages 57-58 Front Matter....Pages 59-59 Living donor in liver transplantation as novel graft source....Pages 61-66 Ex-situ liver support....Pages 67-73 Front Matter....Pages 75-75 Preventing end-stage renal disease: fact or fiction?....Pages 77-95 Transplantation and short daily haemodialysis....Pages 97-105 Comparison of survival probabilities between renal transplant recipients and patients undergoing regular dialysis: a single centre prospective study....Pages 107-114 Transplantation versus dialysis in aged and type II diabetic patients....Pages 115-128 Front Matter....Pages 129-129 External and implantable insulin pumps: current place in the treatment of diabetes....Pages 131-138 Pancreas and islet transplantation in the treatment of type I diabetes....Pages 139-143 Perspectives in early detection and management of IDDM....Pages 145-149 Front Matter....Pages 151-151 Mechanical circulatory support: today’s facts and future horizons....Pages 153-158 Intra-myocardial myoblast injection....Pages 159-162 Ambulatory management of primary pulmonary hypertension....Pages 163-168 Cystic fibrosis: conservative management....Pages 169-172 Front Matter....Pages 173-173 Intestinal transplantation....Pages 175-187 Intracerebral grafting of fetal neuroblasts for neurodegenerative diseases: experimental bases and clinical results....Pages 189-192 Front Matter....Pages 173-173 Skin equivalents....Pages 193-207 Front Matter....Pages 209-209 Public health issues from European countries....Pages 211-225 Clinical evaluation of organ transplantation in France....Pages 227-237 From Lyon to Louisville: the need for tolerance....Pages 239-246 Back Matter....Pages 247-247