Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques (Molecular and Translational Medicine)

__Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques__ provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. __Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques__ simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines. Front Matter....Pages i-xv Relationship Between Myocardial Ischemia/Reperfusion and Time of Day....Pages 1-38 Phosphotransfer Reactions in the Failing Heart....Pages 39-62 Mitochondria in Cardiac Disease....Pages 63-82 PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease....Pages 83-111 AMPK and Metabolic Remodeling in Cardiac Disease....Pages 113-150 Mechanotransduction in Cardiac Hypertrophy and Ischemia....Pages 151-184 Cardiac Plasticity in Health and Disease....Pages 185-250 Ubiquitylation - Dependent Signaling in Heart Disease....Pages 251-289 Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics....Pages 291-316 Molecular Basis of Cardiac Development and Congenital Heart Disease....Pages 317-339 Cellular Therapy for the Infarcted Myocardium....Pages 341-390 Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors....Pages 391-458 Novel Delivery of Molecular Therapeutics to the Heart Using Non-biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy....Pages 459-484 Molecular Imaging of Cardiovascular Disease....Pages 485-531 Back Matter....Pages 533-543 Covering new developments in cellular, viral and non-biological therapies, and with chapters by experts from a range of disciplines, this is an up-to-date survey of the role that circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart.