Transgenic and Knockout Models of Neuropsychiatric Disorders (Contemporary Clinical Neuroscience)

Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today. Transgenic and knockout models of psychiatric disorders: introduction, history, and assessment / Gene S. Fisch Transgenic mouse models and human disease / Jonathan Flint Transgenic and knockout mouse models: the problem of language / Linda J. Hayes and Diana Delgado If only they could talk: genetic mouse models for psychiatric disorders / Trevor Humby and Lawrence Wilkinson SCA1: lessons from modeling a movement disease in mice / Harry T. Orr Mouse models of hereditary mental retardation / Hans Welzl ... [et al.] How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders? / Simon E. Fisher Animal models of autism: proposed behavioral paradigms and biological studies / Thomas Bourgeron, Stephane Jamain, and Sylvie Granon Genetic mouse models of psychiatric disorders: advantages, limitations, and challenges / Joseph A. Gogos and Maria Karayiorgou Animal models of psychoses / Stephen I. Deutsch ... [et al.] Animal models of anxiety: the ethological perspective / Robert Gerlai, Robert Blanchard, and Caroline Blanchard Modeling human anxiety and depression in mutant mice / Andrew Holmes and John F. Cryan Mutant mouse models of bipolar disorder: are there any? / Anneloes Dirks, Lucianne Groenink, and Berend Olivier. Front Matter....Pages i-xii Front Matter....Pages 1-1 Transgenic and Knockout Models of Psychiatric Disorders....Pages 3-23 Transgenic Mouse Models and Human Psychiatric Disease....Pages 25-43 Transgenic and Knockout Mouse Models....Pages 45-67 If Only They Could Talk....Pages 69-83 Front Matter....Pages 85-85 Spinocerebellar Ataxia Type 1....Pages 87-99 Mouse Models of Hereditary Mental Retardation....Pages 101-125 How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?....Pages 127-149 Animal Models of Autism....Pages 151-174 Front Matter....Pages 175-175 Genetic Mouse Models of Psychiatric Disorders....Pages 177-191 Animal Models of Psychosis....Pages 193-220 Animal Models of Anxiety....Pages 221-236 Modeling Human Anxiety and Depression in Mutant Mice....Pages 237-263 Mutant Mouse Models of Bipolar Disorder....Pages 265-285 Back Matter....Pages 287-296

in This Up-to-date Survey And Critical Assessment Of Transgenic And Knockout Models In Neuropsychiatry And Behavior, A Panel Of Leading Researchers Comprehensively Assesses How And Whether The Genetic Abnormalities Produced From These Models Manifest The Neuropsychiatric Disorders To Which They Correspond. The Authors Focus On Transgenic And Knockout Models Of Neurocognitive Dysfunction And Neuropsychiatric Dysfunction. The Discussion Of Neurobiological Problems Covers Mental Retardation, Polyglutamate, And Speech Disorders, As Well As Disorders That Involve Cognitive, Social, Speech, And Language Dysfunction. The Neuropsychiatric Dysfunctions Examined Include Psychosis And Schizophrenia, Anxiety, Depression, And Bipolar Disorder.