Transgenesis And The Management Of Vector-borne Disease (advances In Experimental Medicine And Biology)

Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies. Perspectives on the state of insect transgenics / David A. O'Brochta and Alfred M. Handler Alphavirus transducing systems / Brian D. Foy and Ken E. Olson Paratransgenesis applied for control of tsetse transmitted sleeping sickness / Serap Aksoy, Brian Weiss, and Geoffrey Attardo Bacteria of the genus Asaia: a potential paratransgenic weapon against malaria / Guido Favia ... [et al.] Proposed uses of transposons in insect and medical biotechnology / Peter W. Atkinson The yin and yang of linkage disequilibrium: mapping of genes and nucleotides Conferring insecticide resistance in insect disease vectors / William C. Black IV ... [et al.] Impact of technological improvements on traditional control strategies / Mark Q. Benedict and Alan S. Robinson Insect population suppression using engineered insects / Luke Alphey ... [et al.] Wolbachia-based technologies for insect pest population control / Kostas Bourtzis Using predictive models to optimize wolbachia-based strategies for vector-borne disease control / Jason L. Rasgon Modifying insect population age structure to control vector-borne disease / Peter E. Cook, Conor J. McMeniman, and Scott L. O'Neill Technological advances to enhance agricultural pest management / Thomas A. Miller, Carol R. Lauzon, and David J. Lampe Applications of mosquito ecology for successful insect transgenesis-based disease prevention programs / Thomas W. Scott ... [et al.]. Front Matter....Pages i-xviii Perspectives on the State of Insect Transgenics....Pages 1-18 Alphavirus Transducing Systems....Pages 19-34 Paratransgenesis Applied for Control of Tsetse Transmitted Sleeping Sickness....Pages 35-48 Bacteria of the Genus Asaia : A Potential Paratransgenic Weapon Against Malaria....Pages 49-59 Proposed Uses of Transposons in Insect and Medical Biotechnology....Pages 60-70 The Yin and Yang of Linkage Disequilibrium: Mapping of Genes and Nucleotides Conferring Insecticide Resistance in Insect Disease Vectors....Pages 71-83 Impact of Technological Improvements on Traditional Control Strategies....Pages 84-92 Insect Population Suppression Using Engineered Insects....Pages 93-103 Wolbachia- Based Technologies for Insect Pest Population Control....Pages 104-113 Using Predictive Models to Optimize Wolbachia-Based Strategies for Vector-Borne Disease Control....Pages 114-125 Modifying Insect Population Age Structure to Control Vector-Borne Disease....Pages 126-140 Technological Advances to Enhance Agricultural Pest Management....Pages 141-150 Applications of Mosquito Ecology for Successful Insect Transgenesis-Based Disease Prevention Programs....Pages 151-168 Back Matter....Pages 169-171