Transforming Growth Factor-β in Cancer Therapy, Volume II: Cancer Treatment and Therapy

Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy. This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment. Front Matter....Pages i-xxvi Front Matter....Pages 1-1 Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease....Pages 3-19 Role of Transforming Growth Factor-β in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma....Pages 21-32 TGF-β, Smads and Cervical Cancer....Pages 33-49 TGF-β Signaling and Biglycan in Pancreatic Cancer....Pages 51-62 TGF-β Signaling in Endometrial Cancer....Pages 63-78 TGF-β Ligands, TGF-β Receptors, and Lung Cancer....Pages 79-93 Role of TGF-β in Osteolytic Bone Metastases....Pages 95-123 Hormonal Regulation of Transforming Growth Factor-β in Breast Cancer....Pages 125-132 TGF-β and Progression of Esophageal Cancer....Pages 133-140 TGF-β and HER2/ErbB2 and Breast Cancer Progression....Pages 141-151 TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer....Pages 153-166 Role of Transforming Growth Factor-β in the Kidney — Physiology and Pathology....Pages 167-179 Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis....Pages 181-202 Transforming Growth Factor-β in Brain Functions and Dysfunctions....Pages 203-218 Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment....Pages 219-227 Key Roles of TGF-β and Smad3 in Prostate Cancer....Pages 229-246 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-β Type I Receptor....Pages 247-261 Front Matter....Pages 263-263 High-Throughput Screening of Protein Interaction Networks in the TGFβ Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression....Pages 265-284 Tumor Suppressor and Pro-progression Roles for TGF-β in Breast Cancer....Pages 285-307 Tumor Suppressors p53 and TGFβ Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker....Pages 309-320 Front Matter....Pages 263-263 TGFβ: Roles in DNA Damage Responses....Pages 321-333 The Rationale for and Effects of Targeting TGF-β for Glioma Therapy....Pages 335-351 Tumor Suppressor Functions of TGFβ1 in T Cells....Pages 353-366 Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-β Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization....Pages 367-381 Role of TGF-β in Tumor Protection and Antitumor Immunity....Pages 383-400 Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1....Pages 401-415 Cancer-Associated Fibroblasts and the Role of TGF-β....Pages 417-441 Adoptive Transfer of Tumor Reactive TGF-β Insensitive CD8 + T-cells for Cancer Therapy....Pages 443-461 DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-β Signaling in Breast Cancer....Pages 463-474 Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-β, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities....Pages 475-505 TGF-β Signaling and Vascular Morphogenesis....Pages 507-521 Aberrant Transforming Growth Factor-β Signaling in Human Pancreatic Cancer: Translational Implications....Pages 523-535 TGF-β and Stromal Influences Over Local Tumor Invasion....Pages 537-551 TGF-β at the Crossroads Between Inflammation, Suppression and Cancer....Pages 553-570 Front Matter....Pages 571-571 Transforming Growth Factor-β (TGF-β) Signaling Inhibitors in Cancer Therapy....Pages 573-587 Targeting TGF-β as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy....Pages 589-608 Targeting Transforming Growth Factor-β in Metastasis: In Vitro and In Vivo Mechanisms....Pages 609-634 Targeted Downregulation of TGF-β2 with AP 12009 in Tumor Therapy....Pages 635-651 Modulating TGF-β Receptor Signaling: A Novel Approach of Cancer Therapy....Pages 653-669 Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action....Pages 671-684 Front Matter....Pages 571-571 The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology....Pages 685-696 Soluble Type II Transforming Growth Factor-β Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity....Pages 697-706 Reversal of EMT by Small-Molecule Inhibitors of TGF-β Type I and II Receptors: Implications for Carcinoma Treatment....Pages 707-722 Soluble TGF-β Type III Receptor Suppresses Malignant Progression of Human Cancer Cells....Pages 723-735 Targeting Smad-Dependent TGF-β Signaling with Peptide Aptamers....Pages 737-756 Rationale for Anti-TGF-β Antibody Therapy in Oncology....Pages 757-774 Back Matter....Pages 775-786 Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood. Transforming Growth Factor- A in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- A (TGF- A) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor- A signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor- A superfamily members in normal and tumor biology. The final part details transforming growth factor- A in inflammation and fibrosis. This volumea (TM)s companion, Cancer Treatment in Therapy, examines transforming growth factor- A in other developing and advanced cancers and methods of treatment and therapy. Together, Transforming Growth Factor- A in Cancer Therapy, Vols. 1 and 2, provide researchers and clinicians a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor- A in biology and cancer treatment Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology. V. 1. Basic And Clinical Biology -- V. 2. Cancer Treatment And Therapy. Edited By Sonia Jakowlew. Includes Bibliographical References And Index.