Transforming Growth Factor-Beta in Cancer Therapy, Volume I: Basic and Clinical Biology (Cancer Drug Discovery and Development)

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy. Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer. It is not even 25 years sinceTGF-~ was first isolated and characterized as a dimeric pep­ tide from both human and bovine sources (1-3), but the entire fieldofTGF-~ research has grown and expanded so that it is now a central theme in all of cell biology. There is almost no tissue or organ in the mammalian body in whichTGF-~ does not playa central role in embryonic differentiation or in adult function, and furthermore, malfunction of the normal physiologyofTGF-~can have disastrous consequences in almost all ofthese sites. Therefore, the present comprehensive review of so many aspects ofTGF-~ function is a most welcome attempt to bring together a huge body of experimental data that is of the utmost importance in the field of oncology. Transforming Growth Factor- A in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- A (TGF- A) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor- A signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor- A superfamily members in normal and tumor biology. The final part details transforming growth factor- A in inflammation and fibrosis. This volumea (TM)s companion, Cancer Treatment in Therapy, examines transforming growth factor- A in other developing and advanced cancers and methods of treatment and therapy. Together, Transforming Growth Factor- A in Cancer Therapy, Vols. 1 and 2, provide researchers and clinicians a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor- A in biology and cancer treatment V. 1. Basic And Clinical Biology -- V. 2. Cancer Treatment And Therapy. Edited By Sonia Jakowlew. Includes Bibliographical References And Index.