Transdermal Drug Delivery Systems: Revised and Expanded (Drugs and the Pharmaceutical Sciences)

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulatory approval

In this update of Transdermal drug delivery: developmental issues and research initiatives, Guy (U. of Geneva, U. of Lyon) and Hadgradt (U. of Greenwich, Chatham, UK) note that this edition reflects renewed interest in this drug administration route due to further knowledge and innovations in compounds for transcending the barrier properties of the skin. In this reference volume of 11 contributions providing a state-of-the-field snapshot of advances and continuing challenges, international contributors discuss mathematical models, methods (including minimally invasive ones), and in vitro studies of dermal and transdermal drug delivery. Regulatory issues are also discussed. Though the date of the first edition is not given, it is noted that it was compiled in the late 1980s. Annotation c. Book News, Inc., Portland, OR

"Completely revised and expanded throughout, the Second Edition of Transdermal Drug Delivery presents discussions of the key issues pertinent to transdermal drug delivery, examining topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin, from physical chemistry and assessment of drug permeability to available enhancement technologies, to regulatory approval. This reference work describes how to determine the transdermal permeability of drugs, how rationally to select candidates for transdermal delivery, how to choose chemical and/or physical methods to enhance skin transport, and how to solve regulatory issues."--Jacket This text presents authoritative, state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin Fortunately for us, the skin has evolved into an extremely efficient barrier, which prevents both excessive water loss from the body and the ingress of xenobiotics.