Tracer kinetics and physiologic modeling : theory to practice : proceedings of a seminar, held at St. Louis, Missouri, June 6, 1983

Front Matter....Pages I-VIII The Statistical Analysis of Pharmacokinetic Data....Pages 1-58 Mathematical Methods in The Formulation of Pharmacokinetic Models....Pages 59-119 New Approaches to Uptake by Heterogeneous Perfused Organs: From Linear to Saturation Kinetics....Pages 120-201 Basic Principles Underlying Radioisotopic Methods for Assay of Biochemical Processes in Vivo ....Pages 202-234 Tracer Studies of Peripheral Circulation....Pages 235-297 Tracer Kinetic Modeling in Positron Computed Tomography....Pages 298-344 Pharmacokinetic Models and Positron Emission Tomography: Studies of Physiologic and Pathophysiologic Conditions....Pages 345-383 Kinetic Analysis of the Uptake of Glucose and Some of its Analogs in the Brain Using the Single Capillary Model: Comments on Some Points of Controversy....Pages 384-407 The Use of 11 C-Methyl-D-Glucose for Assessment of Glucose Transport in the Human Brain; Theory and Application....Pages 408-428 The Indicator Dilution Method: Assumptions and Applications to Brain Uptake....Pages 429-444 Measurement of Receptor-Ligand Binding: Theory and Practice....Pages 445-507 Back Matter....Pages 509-512