Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series)

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Updated to reflect the latest research in the field, Toxicology of the Kidney, Third Edition focuses on the correlation between the anatomy, biochemistry, and physiology of the kidney. The text seeks to explain how this correlation is related to concepts of clinical nephrotoxicity, and renal failure in humans and how animal models can be used to understand the mechanisms of human renal disease. Book Cover......Page 1 Title......Page 4 Copyright......Page 5 Contents......Page 6 Preface......Page 9 Contributors......Page 10 The Editors......Page 15 Part I: Basic Principles......Page 18 1. Anatomy and Physiology of the Kidneys......Page 20 2. Molecular and Cell Biology of Normal and Diseased or Intoxicated Kidney......Page 72 3. Assessing Renal Effects of Toxicants In Vivo......Page 92 4. In vitro Techniques in Screening and Mechanistic Studies: Organ Perfusion, Slices, and Nephron Components......Page 144 5. In Vitro Techniques in Screening and Mechanistic Studies: Cell Culture, Cell-Free Systems, and Molecular and Cell Biology......Page 178 Part II: Mechanisms of Nephrotoxicity......Page 197 6. Role of Xenobiotic Metabolism......Page 199 7. Mechanisms of Renal Cell Death......Page 224 8. Signal Transduction in Renal Cell Repair and Regeneration......Page 268 9. Chemical-Induced Nephrocarcinogenicity in the Eker Rat: A Model of Chemical-Induced Renal Carcinogenesis......Page 303 10. The Role of Endocytosis in Nephrotoxicity......Page 332 11. Role of Cellular Energetics in Nephrotoxicity......Page 378 12. Adhesion Molecules in Renal Physiology and Pathology......Page 418 13. Oxidant Mechanisms in Toxic Acute Renal Failure......Page 438 Part III: Clinical Nephrotoxicity and Specific Classes of Nephrotoxicants......Page 459 14. Vasoactive and Inflammatory Substances......Page 461 15. Analgesic Nephropathy......Page 531 16. Antibiotic-Induced Nephrotoxicity......Page 544 17. Nephrotoxicity of Cyclosporine and Other Immunosuppressive and Immunotherapeutic Agents......Page 587 18. Cisplatin-Induced Nephrotoxicity......Page 657 19. The Pathogenesis and Prevention of Radiocontrast Medium Induced Renal Dysfunction......Page 688 20. Analgesics and Nonsteroidal Anti-Inflammatory Drugs......Page 723 21. Mycotoxins Affecting the Kidney......Page 751 22. Nephrotoxicology of Metals......Page 784 23. Chemical-Induced Nephrotoxicity Mediated by Glutathione S-Conjugate Formation......Page 833 Part IV: Risk and Safety Assessment......Page 855 24. The Role of Epidemiology in Human Nephrotoxicity......Page 857 25. Age, Sex and Species Differences in Nephrotoxic Response......Page 885 26. Risk Assessment of Nephrotoxic Metals......Page 915 27. Risk Assessment for Selected Therapeutics......Page 944 Index......Page 969

The kidney plays a vital role in certain endocrine functions. Abnormalities caused by toxic chemicals or other interventions can have profound effects on these functions and consequently, on total functions. Toxicology of the Kidney, Third Edition is updated to reflect the latest research in this field and focuses on the correlation between anatomy, biochemistry, and physiology of the kidney.

The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease. In addition to updating many of the key elements of previous editions, such as in vitro models for studying renal function and toxicity and classic nephrotoxicants, it also incorporates cutting edge information on newly emerging areas of renal research. These include mechanisms of cell injury, signaling pathways, biomarkers of renal disease and the interface between basic renal science and clinical outcomes.

This book includes current reviews of unpublished and recently published information which allows it to serve as a concise compendium of many key topics that will continue to play a central role in our understanding and treatment of nephrotoxicity for decades to come.

"Updated to reflect the latest research in this field, Toxicology of the Kidney, Third Edition explores the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease." "In addition to updating many of the key elements of previous editions, the book incorporates cutting-edge information on newly emerging areas of renal research. Filled with current reviews of unpublished and recently published information, the book is a concise compendium of many key topics that will continue to play a central role in understanding and treating nephrotoxicity for decades to come."--BOOK JACKET