Toxic Phosphorus Esters. Chemistry, Metabolism, and Biological Effects

Content: Front Matter , Page iii Copyright , Page iv Dedication , Page v Preface , Pages vii-viii CHAPTER 1 - Introduction , Pages 1-28 CHAPTER 2 - Nonenzymic Reactions , Pages 29-71 CHAPTER 3 - The Reaction with Cholinesterase in Vitro , Pages 73-113 CHAPTER 4 - Enzymic Degradation and Activation in Vitro , Pages 115-147 CHAPTER 5 - Effects on Isolated Whole Tissues , Pages 149-174 CHAPTER 6 - Effects in Mammals , Pages 175-239 CHAPTER 7 - Effects in Insects , Pages 241-287 CHAPTER 8 - Effects in Plants , Pages 289-313 CHAPTER 9 - Selective Toxicity , Pages 315-343 CHAPTER 10 - Techniques , Pages 345-380 APPENDIX 1 - Electronic Interpretations , Pages 381-389 APPENDIX 2 - Structure of Organophosphates , Pages 391-399 AUTHOR INDEX , Pages 401-414 SUBJECT INDEX , Pages 415-434 Toxic Phosphorus Esters: Chemistry, Metabolism, and Biological Effects aims to become a source book on organophosphate research and show how the understanding of the events following organophosphate poisoning of animals can be understood in terms of events at the molecular level. The manuscript first offers information on nonenzymic reactions and the reaction with cholinesterase in vitro. Discussions focus on hydrolysis, isomerization, oxidation, phosphorylation of the enzyme, and selectivity for different cholinesterases. The text then examines enzymic degradation and activation in vitro, eff ..