Topics in Applied Statistics: 2012 Symposium of the International Chinese Statistical Association (Springer Proceedings in Mathematics & Statistics Book 55)

This volume presents 27 selected papers in topics that range from statistical applications in business and finance to applications in clinical trials and biomarker analysis. All papers feature original, peer-reviewed content. The editors intentionally selected papers that cover many topics so that the volume will serve the whole statistical community and a variety of research interests. The papers represent select contributions to the 21 st ICSA Applied Statistics Symposium. The International Chinese Statistical Association (ICSA) Symposium took place between the 23 rd and 26 th of June, 2012 in Boston, Massachusetts. It was co-sponsored by the International Society for Biopharmaceutical Statistics (ISBS) and American Statistical Association (ASA). This is the inaugural proceedings volume to share research from the ICSA Applied Statistics Symposium. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Constructing and Evaluating an Autoregressive House Price Index....Pages 3-12 On Portfolio Allocation: A Comparison of Using Low-Frequency and High-Frequency Financial Data....Pages 13-22 Applications of Functional Dynamic Factor Models....Pages 23-37 Mixed Modeling for Physician-Direct Campaigns....Pages 39-47 Uplift Modeling Application and Methodology in Database Marketing....Pages 49-60 Front Matter....Pages 61-61 Designing Studies for Assessing Efficacy in Mixture Populations....Pages 63-73 Estimating Subject-Specific Treatment Differences for Risk-Benefit Assessment with Applications to Beta-Blocker Effectiveness Trials....Pages 75-86 Missing Data in Principal Surrogacy Settings....Pages 87-97 Assessment of Treatment-Mediated Correlation Between a Clinical Endpoint and a Biomarker....Pages 99-110 Biomarker Selection in Medical Diagnosis....Pages 111-121 Front Matter....Pages 123-123 Safety Concerns of the 3+3 Design: A Comparison to the mTPI Design....Pages 125-135 Bayesian Interim Inference of Probability of Clinical Trial Success....Pages 137-147 Bayesian Survival Analysis Using Log-Linear Median Regression Models....Pages 149-158 Bayesian Analysis of Survival Data with Semi-competing Risks and Treatment Switching....Pages 159-169 Front Matter....Pages 171-171 High-Dimensional Ordinary Differential Equation Models for Reconstructing Genome-Wide Dynamic Regulatory Networks....Pages 173-190 Kernel Methods for Regression Analysis of Microbiome Compositional Data....Pages 191-201 A Conditional Autoregressive Model for Detecting Natural Selection in Protein-Coding DNA Sequences....Pages 203-212 Dimension Reduction for Tensor Classification....Pages 213-227 Successive Standardization: Application to Case-Control Studies....Pages 229-239 Front Matter....Pages 241-241 Quantification of PFS Effect for Accelerated Approval of Oncology Drugs....Pages 243-256 Front Matter....Pages 241-241 Integrative Analysis of Multiple Cancer Prognosis Datasets Under the Heterogeneity Model....Pages 257-269 Front Matter....Pages 271-271 On Analysis of Low Incidence Adverse Events in Clinical Trials....Pages 273-282 Statistical Power to Detect Cardiovascular Signals in First-in-Human Trials: Is It Really Small?....Pages 283-295 Front Matter....Pages 297-297 Constructing Conditional Reference Charts for Grip Strength Measured with Error....Pages 299-310 Hierarchical Bayesian Analysis of Repeated Binary Data with Missing Covariates....Pages 311-322 Front Matter....Pages 323-323 Use of Random Effect Models in the Design and Analysis of Multi-regional Clinical Trials....Pages 325-334 Front Matter....Pages 335-335 Experimental Design for In Vitro Drug Combination Studies....Pages 337-344 The 21st Icsa Applied Statistics Symposium Took Place Between The 23rd And 26th Of June, 2012 In Boston, Massachusetts. The Symposium Was Co-sponsored By The International Society For Biopharmaceutical Statistics (isbs) And American Statistical Association (asa). This Is The First Proceedings Volume To Share Research From The Icsa Applied Statistics Symposium. The Volume Consists Of 27 Selected Papers From Topics That Range From Statistical Applications In Business And Finance To Applications In Clinical Trials And Biomarker Analysis. All Papers Feature Original, Peer-reviewed Content. The Editors Intentionally Selected Papers As Broad As Possible To Serve The Whole Statistical Community And The Vast Variety In Research Interests. Bayesian Statistics In Clinical Trials -- High-dimensional Data Analysis: Survival Analysis -- Adaptive Designs -- Statistics In Business And Finance -- Biomarker Analysis -- Statistical Genetics And Genomics -- Data Mining And Statistical Learning. Edited By Mingxiu Hu, Yi Liu, Jianchang Lin.