Topics and Perspectives in Adenosine Research : Proceedings of the 3rd International Symposium on Adenosine, Munich, June 1986

An "International Conference on Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides" was held in Banff, Canada, in June 1978. Four years later, in June 1982, an "International Symposium on Adenosine" took place in Charlottesville, Virginia, USA. Both meetings revealed an increasing interest of scientists from numerous disciplines on biochemical, physiological and pathophysiological aspects of adenosine as a proposed mediator of various specified regulatory functions, both on the cellular and organ level. In view of the obvious continuity of adenosine research in well-established and newly emerging fields, a scientific committee was charged with organizing a further meeting to be held in Munich, Germany, in June 1986. Members of the committee were H. P. Baer, Canada, R. M. Berne, USA, and E. Gerlach, G. W. Kreutzberg and J. Schrader, FRG. It was the general intention that in this conference, purposely named "3rd International Symposium on Adenosine", emphasis should be placed on the presentation of shorter reports concerning both latest as well as controversial aspects and developments in as wide a scope of adenosine research as possible. Therefore, in addition to more than 50 presentations by invited speakers, over 120 posters were displayed. Coinciding with the symposium, abstracts of all contributions were published in Pfltigers Archiv - European Journal of Physiology [Vol. 407, Suppl. 1, 1986]. This book, entitled "Topics and Perspectives in Adenosine Research", now enholds all papers presented at the 3rd International Symposium on Adenosine, together with the complete discussions following each talk. Front Matter....Pages I-XIV Front Matter....Pages 1-1 Agonist and Antagonist Radioligands and Photoaffinity Labels for the Adenosine A 1 Receptor....Pages 3-14 Functional Characterization of A 1 Adenosine Receptors by Photoaffinity Labelling....Pages 15-22 Analogues of Adenosine, Theophylline, and Caffeine: Selective Interactions with A 1 and A 2 Adenosine Receptors....Pages 23-36 Structural Studies on Adenosine R i Receptors from Rat Cerebral Cortex....Pages 37-48 Biochemical and Autoradiographic Approaches to the Characterization of Adenosine Receptors in Brain....Pages 49-58 Adenosine Receptor Subtypes: Binding Studies....Pages 59-73 Central Sites of Adenosine Action and Their Interaction with Various Drugs....Pages 74-88 Nucleoside Transport Inhibition In Vitro and In Vivo....Pages 89-101 Kinetic and Molecular Properties of Nucleoside Transporters in Animal Cells....Pages 102-117 Drug Interactions with Nucleoside Transport Systems....Pages 118-130 Front Matter....Pages 131-131 Regulation and Function of 5′-Nucleotidases....Pages 133-144 Kinetics of Endothelial Cell Ectonucleotidases....Pages 145-154 Critical Evaluation of the Role of Ecto- and Cytosolic 5′-Nucleotidase in Adenosine Formation....Pages 155-169 New Insights into the Mechanism of Myocardial Adenosine Formation....Pages 170-187 Cardiac Myocyte and Coronary Endothelial Cell Adenosine Transport....Pages 188-198 The Importance of the Transmethylation Pathway for Adenosine Metabolism in the Heart....Pages 199-208 Uric Acid, the Major Catabolite of Cardiac Adenine Nucleotides and Adenosine, Originates in the Coronary Endothelium....Pages 209-222 Thermodynamic State of Cytosolic Adenylates in Guinea Pig Myocardium. Energy-Linked Adaptive Changes in Free Adenylates and Purine Nucleoside Release....Pages 223-235 Front Matter....Pages 237-237 On Multiple Targets for Fat Cell Receptors....Pages 239-248 The Renal and Epithelial Actions of Adenosine....Pages 249-260 Front Matter....Pages 237-237 Adenosine and Thermogenesis in Brown Adipose Tissue: Interaction with Beta and Alpha Adrenergic Responses....Pages 261-274 The Hormone-Modulatory Effects of Adenosine in Skeletal Muscle....Pages 275-285 Effects of Adenosine on Human Neutrophil Function and Cyclic AMP Content....Pages 286-298 A New Function for Adenosine: Protection of Vascular Endothelial Cells from Neutrophil-Mediated Injury....Pages 299-308 Formation of Adenosine by Vascular Endothelium: a Homeostatic and Antithrombogenic Mechanism?....Pages 309-320 Front Matter....Pages 321-321 Ionic Channels and Adenosine in Isolated Heart Cells....Pages 323-335 The Negative Chronotropic Effect of Adenosine in Sinus Node Cells....Pages 336-343 Regulation of Atrioventricular Node Function by Adenosine....Pages 344-355 The Antiadrenergic Actions of Adenosine in the Heart....Pages 356-368 Mechanism of the “Antiadrenergic” Effects of Adenosine on Myocardial Force of Contraction....Pages 369-382 Further Evidence Against Adenosine-Catecholamine Antagonism In Vivo: Investigations with Treadmill Exercise in Dogs....Pages 383-394 Adenosine in the Local Regulation of Blood Flow: Some Controversies....Pages 395-405 Adenosine in the Local Regulation of Blood Flow: Current Controversies....Pages 406-415 5′-Nucleotidase Inhibitors and the Myocardial Reactive Hyperemia and Adenosine Content....Pages 416-424 Estimates of Interstitial Adenosine in Isolated Rat Hearts from Surface Exudates During Rapid Pacing and EHNA Infusion....Pages 425-438 Intra-Arterial Adenosine Deaminase: a Tool for Assessing Physiologic Functions of Adenosine....Pages 438-444 A Critique on the Use of Adenosine Deaminase to Test the Adenosine Hypothesis: Disregarded Implicit Assumptions....Pages 445-453 Adenosine Receptors at the Coronary Endothelium: Functional Implications....Pages 454-469 Endothelial Activation by Adenosine and Coronary Flow Regulation in the Guinea Pig Heart....Pages 470-479 Cellular Compartmentation of Adenosine in the Heart....Pages 480-485 Front Matter....Pages 321-321 Mechanisms of Adenosine- and ATP-Induced Relaxation in Rabbit Femoral Artery: Role of the Endothelium and Cyclic Nucleotides....Pages 486-496 Front Matter....Pages 497-497 Mechanisms Underlying Physiological Responses to Adenosine in the Central Nervous System....Pages 499-508 Interactions Between the Neuromodulator Adenosine and the Classic Transmitters....Pages 509-520 Pre- Versus Postsynaptic Effects of Adenosine on Neuronal Calcium Fluxes....Pages 521-532 Adenosine-Mediated Presynaptic Inhibiton of Sympathetic Innervation as an Explanation of Functional Hyperemia....Pages 533-536 Intracellular Calcium Mediating the Actions of Adenosine at Neuromuscular Junctions....Pages 537-548 Inhibition of Calcium Currents by an Adenosine Analogue 2-Chloroadenosine....Pages 549-558 Adenosine, Cyclic AMP and Nerve Conduction....Pages 559-573 The Role of Adenosine Neuromodulation in Postanoxic Hyperexcitability....Pages 574-585 Role of Adenosine in the Regulation of Breathing....Pages 586-596 Front Matter....Pages 597-597 Levels and Cardiovascular Effects of Adenosine in Humans....Pages 599-613 The Bronchoconstrictor Activity of Adenosine in Asthma....Pages 614-624 Adenosine Deaminase Deficiency: Recent Observations Pertinent to Investigation of the Physiologic Role of Adenosine in Man....Pages 625-629 Back Matter....Pages 630-634