Toll-Like Receptors (TLRs) and Innate Immunity (Handbook of Experimental Pharmacology (183))

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention. Front Matter....Pages i-xi Toll-Like Receptors (TLRs) and Their Ligands....Pages 1-20 Signalling of Toll-Like Receptors....Pages 21-50 TLR9-Mediated Recognition of DNA....Pages 51-70 RNA Recognition via TLR7 and TLR8....Pages 71-86 Fungal Recognition by TLR2 and Dectin-1....Pages 87-109 Heat Shock Proteins and Toll-Like Receptors....Pages 111-127 Nucleic Acid Recognition Receptors in Autoimmunity....Pages 129-151 Dendritic Cell Subsets and Toll-Like Receptors....Pages 153-179 Structure of Toll-Like Receptors....Pages 181-200 Toll-Like Receptor-Agonists in the Treatment of Skin Cancer: History, Current Developments and Future Prospects....Pages 201-220 Vaccination with Messenger RNA (mRNA)....Pages 221-235 Back Matter....Pages 237-240