Toll-like Receptors: Roles in Infection and Neuropathology (Current Topics in Microbiology and Immunology Book 336)

Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second half of the volume discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands. Several conceptual theories are introduced in various chapters that deal with the dual nature of TLR engagement and whether these signals favor neuroprotective versus neurodegenerative outcomes. This volume should be informative for both experts as well as newcomers to the field of TLRs in the nervous system based on its coverage of basic TLR biology as well as specialization to discuss specific diseases of the nervous system where TLR function has been implicated. A must read for researchers interested in the dual role of these receptors in neuroinfection and neurodegeneration. Overview Of Toll-like Receptors In The Cns / T. Kielian -- Toll-like Receptors In Bacterial Meningitis / U. Koedel -- Toll-like Receptors In Brain Abscess / N. Esen And T. Kielian -- Toll-like Receptors In Cns Viral Infections / H.-s. Suh, C.f. Brosnan And S.c. Lee -- Toll-like Receptors In Cns Parasitic Infections / B.b. Mishra, U.m. Gundra And J.m. Teale -- Toll-like Receptors In Neurodegeneration / T. Owens -- Toll-like Receptors In Spinal Cord Injury / K.a. Kigerl And P.g. Popovich -- Toll-like Receptors In Alzheimer's Disease / G.e. Landreth And E.g. Reed-geaghan -- Toll-like Receptors In Multiple Sclerosis / M.k. Racke And P.d. Drew -- Toll-like Receptors In Peripheral Nerve Injury And Neuropathic Pain / D. Kim, S. Lee And S.j. Lee. Tammy Kielian, Editor. Includes Bibliographical References And Index. Front Matter....Pages i-xi Overview of Toll-Like Receptors in the CNS....Pages 1-14 Toll-Like Receptors in Bacterial Meningitis....Pages 15-40 Toll-Like Receptors in Brain Abscess....Pages 41-61 Toll-Like Receptors in CNS Viral Infections....Pages 63-81 Toll-Like Receptors in CNS Parasitic Infections....Pages 83-104 Toll-Like Receptors in Neurodegeneration....Pages 105-120 Toll-Like Receptors in Spinal Cord Injury....Pages 121-136 Toll-Like Receptors in Alzheimer's Disease....Pages 137-153 Toll-Like Receptors in Multiple Sclerosis....Pages 155-168 Toll-Like Receptors in Peripheral Nerve Injury and Neuropathic Pain....Pages 169-186 Back Matter....Pages 187-191 Highlights more traditional roles for TLRs in infectious diseases of the CNS. This volume discusses various roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands