Tobacco smoking addiction : epidemiology, genetics, mechanisms, and treatment

This book provides the most recent knowledge on almost all key aspects of the health impact of tobacco smoking. Its 21 chapters focus on both preclinical and clinical studies. The contents are broad, covering the epidemiology of tobacco smoking; genetic epidemiology; identification of susceptibility genomic regions, genes, and pathways as determined by both human and animal studies; evolutionary relations among the different nAChR subunit genes that are so important to the nicotine response; smoking-related diseases; E-cigarettes; and smoking cessation. Furthermore, each chapter includes a detailed and comprehensive list of key references. For both clinical and basic researchers, this book is a valuable resource on nicotine dependence and other addictions. Front Matter ....Pages i-xiii The Prevalence of Smoking and Its Associated Diseases (Ming D. Li)....Pages 1-11 Addiction Genetics: Basic Concepts and Techniques (Ming D. Li)....Pages 13-21 Estimation of Genetic and Environmental Contributions to Smoking Addiction (Ming D. Li)....Pages 23-34 Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses (Ming D. Li)....Pages 35-46 Involvement of Variants in Gene Clusters CHRNA5/A3/B4 on Chromosome 15 to Smoking Behaviors and Lung Cancer (Ming D. Li)....Pages 47-69 Contribution of Variants in CHRNB3/A6 Gene Cluster on Chromosome 8 to Smoking Dependence (Ming D. Li)....Pages 71-93 Genetic Contribution of Variants in GABAergic Signaling to Nicotine Dependence (Ming D. Li)....Pages 95-105 Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions (Ming D. Li)....Pages 107-142 Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Smoking Dependence (Ming D. Li)....Pages 143-152 Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction (Ming D. Li)....Pages 153-181 Contribution of Gene–Gene and Gene–Environment Interactions to Tobacco Smoking (Ming D. Li)....Pages 183-197 Identification of Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation (Ming D. Li)....Pages 199-213 Neuroproteomics and Its Applications in Research on Nicotine and Other Drugs of Abuse (Ming D. Li)....Pages 215-242 Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases (Ming D. Li)....Pages 243-262 Tobacco Smoking, Food Intake, and Weight Control (Ming D. Li)....Pages 263-286 Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor (Ming D. Li)....Pages 287-302 DNA Methylation Analysis Reveals a Strong Connection Between Tobacco Smoking and Cancer Pathogenesis (Ming D. Li)....Pages 303-317 Evolutionary Relations of Genes Encoding Nicotinic Acetylcholine Receptor Subunits (Ming D. Li)....Pages 319-338 Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation (Ming D. Li)....Pages 339-349 Background, Biology and Health Concerns of Electronic Cigarettes (Ming D. Li)....Pages 351-359 Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research (Ming D. Li)....Pages 361-365