Tissue Repair and Fibrosis : The Role of the Myofibroblast

Specialists from diverse disciplines discuss the important topics of Tissue Repair and Fibrosis. The Role of Myofibroblast. The Myofibroblast is implicated in many processes, such as tissue repair,fibrosis, and stromal reaction to tumors. This book seeks to provide an overview of the knowledge accumulated since this cell was first describes 25 years ago. Discussions focusses on three main topics: - Cellular and molecular biology of fibroblast and myofibroblasts - Wound healing: experimental models, and - Human fibrocontracted diseases. Front Matter....Pages I-XVIII Some Historical and Philosophical Reflections on the Myofibroblast Concept....Pages 1-5 Transcriptional Regulation of the Desmin and SM22 Genes in Vascular Smooth Muscle Cells....Pages 7-17 Modulation of Myofibroblast and Smooth-Muscle Phenotypes in the Lung....Pages 19-26 Role of Platelet-Derived Growth Factors in Angiogenesis and Alveogenesis....Pages 27-33 Transforming Growth Factor- β Gene Transfer to the Lung Induces Myofibroblast Presence and Pulmonary Fibrosis....Pages 35-45 Transforming Growth Factor- β Induction of α -Smooth Muscle Actin Is Dependent on the Deformability of the Collagen Matrix....Pages 47-60 Signal Transduction Pathways Activated During Fibroblast Contraction of Collagen Matrices....Pages 61-73 Extracellular Matrix, Integrins and Focal Adhesions....Pages 75-85 What Is New in Mechanical Properties of Tissue-Engineered Organs....Pages 87-93 Fibroblast — Cytokine — Extracellular Matrix Interactions in Wound Repair....Pages 95-101 Myofibroblastic Differentiation and Extracellular Matrix Deposition in Early Stages of Cholestatic Fibrosis in Rat Liver....Pages 103-109 Gene Therapy of Wounds with Growth Factors....Pages 111-121 What’s New in Human Wound-Healing Myofibroblasts?....Pages 123-133 The Myofibroblast in Neoplasia....Pages 135-148 The Concept of Organizing Pneumonia....Pages 149-156 Endothelial Repair in Atherogenesis....Pages 157-166 Glomerulosclerosis: The Role of Interstitial Myofibroblasts in its Progression....Pages 167-171 The Myofibroblast as an Inflammatory Cell in Pulmonary Fibrosis....Pages 173-182 Cell—Cell and Cell—Matrix Interactions During Breast Cancer Progression....Pages 183-193 Hepatocyte Growth Factor Secreted by Human Liver Myofibroblasts Increases Invasiveness of Hepatocellular Carcinoma Cells....Pages 195-203 Interplay of Matrix and Myofibroblasts During Hepatic Fibrogenesis....Pages 205-218 Back Matter....Pages 219-224 Specialists from diverse disciplines discuss the important topics of Tissue Repair and Fibrosis. The Role of Myofibroblast. The Myofibroblast is implicated in many processes, such as tissue repair, fibrosis, and stromal reaction to tumors. This book seeks to provide an overview of the knowledge accumulated since this cell was first describes 25 years ago. Discussions focusses on three main topics: - Cellular and molecular biology of fibroblast and myofibroblasts - Wound healing: experimental models, and - Human fibrocontracted diseases