Thymic Hormones And Lymphokines: Basic Chemistry And Clinical Applications (gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia)

The Third Annual Symposium on Health Sciences attracted over 400 scientists from 15 countries. It was held at the National Academy of Sciences in Washington, D.C. The theme of this meeting was "Thymic Hormones and Lymphokines: Basic Chem­ istry and Clinical Applications." The meeting emphasized the state of the art with regard to chemistry, mech­ anism of action, and clinical applications of thymic hormones and lymphokines. In addition to the five sessions, the chairmen of each session were asked to prepare a synthesis and overview of each of the sessions. Some of the chairmen used this time to summarize the new material presented while others addressed important areas of conflict and terminology. The chairmen of the plenary sessions prepared short summary papers which have been incorporated into this volume at the end of each major section. We also invited several of the scientists who took part in the poster presentations to submit short papers. In addition to the scientific sessions, there were two awards and lectures. One, the Abraham White Distinguished Science Award, was given to Dr. Robert C. Gallo, who gave the keynote lecture. He was recognized for his pioneering research and scientific contributions to our understanding of the regulation of hematopoietic cell differentiation and the role of viruses in the development of human leukemias. Front Matter....Pages i-xiii Human T-Cell Growth Factor, Growth of Human Neoplastic T Cells, and Human T-Cell Leukemia-Lymphoma Virus....Pages 1-17 Front Matter....Pages 19-19 Thymosins....Pages 21-35 Thymulin....Pages 37-42 Use of Monoclonal Antibodies to Identify Antigens of Human Endocrine Thymic Epithelium....Pages 43-56 Abnormal Levels of Thymosin α 1 and the Destruction of the Thymus Gland in the Acquired Immune Deficiency Syndrome....Pages 57-60 Thymic Epithelial Injury in the Acquired Immune Deficiency Syndrome....Pages 61-67 Increased Thymosin Levels Associated with Acquired Immune Deficiency Syndrome....Pages 69-76 Thymosin β 4 ....Pages 77-88 The Finding and Significance of Spermidine and Spermine in Thymic Tissue and Extracts....Pages 89-95 Synthetic Small Thymic Peptides....Pages 97-109 Human Peripheral Blood Lymphocytes Bear Markers for Thymosins (α 1 , α 7 , β 4 )....Pages 111-117 Thymosin β 4 Is Present in a Subset of Oligodendrocytes in the Normal Human Brain....Pages 119-125 The Synthesis and Physical Properties of Thymosin α 1 and Its Analogs Prepared by Fragment Condensation....Pages 127-134 Immunocytochemical Localization of Thymosin and Thymopoietin in Human, Rat, and Murine Thymus....Pages 135-143 Thymus- and Spleen-Derived Immunosuppressive Peptides....Pages 145-154 Production of a Thymosin α 1 -like Material by T-Cell Lymphomas....Pages 155-163 Purification and Characterization of an Immunoreactive Thymosin α 1 from Human Blood....Pages 165-173 Front Matter....Pages 179-179 Characterization of Immunoaffinity-Purified Human T-Cell Growth Factor from JURKAT Cells....Pages 181-189 The Use of Lymphoid Cells Expanded in IL-2 for the Adoptive Immunotherapy of Murine and Human Tumors....Pages 191-207 Biochemical and Biological Properties of Interleukin-3....Pages 209-222 Front Matter....Pages 179-179 Lymphotoxins, a Multicomponent Family of Effector Molecules....Pages 223-233 Chemical and Biological Properties of Human Lymphotoxin....Pages 235-245 T-Cell Growth Factor....Pages 247-256 Demonstration and Characterization of Human Intracellular Interleukin-1....Pages 257-264 Silicic Acid Batch Adsorption Procedure for the Partial Purification of Interleukin-2 from Cultures of Primary Lymphocytes and Long-Term T-Cell Lines....Pages 265-272 TCGF (IL-2) Receptor (Tac Antigen) on ATL and Non-ATL Leukemic Cells....Pages 273-277 Front Matter....Pages 283-283 Lymphocyte Proliferation, Lymphokine Production, and Lymphocyte Receptors in Aging....Pages 285-295 Augmentation of Antibody Synthesis in Vitro by Thymosin Fraction 5....Pages 297-305 The Production and Characterization of Monoclonal Antibodies to Lymphokines....Pages 307-312 Modulatory Interactions between the Central Nervous System and the Immune System....Pages 313-323 Effects of Thymic Peptides on Hypothalamic-Pituitary Function....Pages 325-334 Biochemistry of Lymphokine Action on Macrophages....Pages 335-346 Modulation of Macrophage Phenotypes by Migration Inhibitory Factors....Pages 347-355 The Anticancer Action of Lymphotoxin....Pages 357-364 Pituitary Responses to Acute Administration of Thymosin and to Thymectomy in Prepubertal Primates....Pages 365-374 Expression of T-Cell Markers on Chicken Bone Marrow Precursor Cells Incubated with an Avian Thymic Hormone....Pages 375-382 Transferrin Receptor Induction in Mitogen-Stimulated Human T Lymphocytes Is Required for DNA Synthesis and Cell Division and Is Regulated by Interleukin-2 (TCGF)....Pages 383-394 Front Matter....Pages 399-399 Phase I Trial of Intravenous Lymphokine MAF....Pages 401-412 Interaction of Thymic Hormones with Prostaglandins....Pages 413-419 A Small-Molecular-Weight Growth Inhibitory Factor (SGIF) in Stationary-Phase Supernatants of Tissue Cultures....Pages 421-423 Front Matter....Pages 399-399 Efficacy of Thymosin α 1 in Animal Models....Pages 425-438 The in Vivo Effect of Thymosin on Cell-Mediated Immunity....Pages 439-443 Effect of Thymosin α 1 on Immunoregulatory T Lymphocytes....Pages 445-453 Treatment of the Diabetic, Autoimmune db/db Mouse with Thymosin....Pages 455-461 Role of Thymosin Fraction 5 in Host Defenses to Leukemia in Nutritionally Stressed Mice....Pages 463-468 Tumor Growth, Interleukins, and Immune Complexes....Pages 469-474 Interleukin-3 Production and Action in Tumor-Bearing Hosts....Pages 475-481 Lymphokine-Mediated Enhancement of Antibody Formation by Leukemic Cells....Pages 483-488 Front Matter....Pages 495-495 A Phase I Trial of Immune Interferon....Pages 497-506 The Response of Tumor-Bearing Patients to the Injection of Lymphoid Cell Line Lymphokine....Pages 507-517 Clinical Studies of Lymphoid Cell Lymphokines in 102 Patients with Malignant Solid Tumors....Pages 519-524 Regulation of T-Cell Proliferation by Interleukin-2 in Male Homosexuals with Acquired Immune Deficiency Syndrome....Pages 525-529 Incorporation of Porcine Thymic Peptides into the Treatment of Fulminant Viral Hepatitis....Pages 531-540 Use of Porcine Thymic Immunomodulator in the Treatment of Chronic Hepatitis B....Pages 541-544 Biological Properties and Clinical Use of Calf Thymus Extract TFX-Polfa....Pages 545-564 Role of Thymostimulin (TP-1) as an Immunomodulator in Hodgkin’s Disease....Pages 565-570 Thymosin Fraction 5 Treatment of Patients with Cellular Immunodeficiency Disorders....Pages 571-577 Effect of Thymosin on in Vitro Immune Function in Patients with Rheumatoid Arthritis....Pages 579-585 Phase I Trial Using Thymosin Fraction 5 in Renal Cancer....Pages 587-591 Clinical Aspects of Thymulin (FTS)....Pages 593-600 Front Matter....Pages 495-495 An Evaluation of Two Different Schedules of Synthetic Thymosin α 1 Administration in Patients with Lung Cancer....Pages 601-613 Effect of Thymosin Fraction 5 on Purine Enzymes and Surface Markers in Lymphocytes from Normal Individuals and Homosexuals with Acquired Immune Deficiency Syndrome....Pages 615-621 Demonstration of a Block at an Early Stage of T-Cell Differentiation in Severe Combined Immunodeficiency Disease....Pages 623-628 Back Matter....Pages 637-669