Thrombosis And Hemostasis In Cancer (cancer Treatment And Research)

In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike. Front Matter ....Pages i-xiv Thrombosis and Hemostasis in Cancer. Scope of the Problem and Overview (Gerald Soff)....Pages 1-9 Pathophysiology 1. Mechanisms of Thrombosis in Cancer Patients (Anna Falanga, Francesca Schieppati, Laura Russo)....Pages 11-36 Pathophysiology 2: The Role of Platelets in Cancer Biology (Aime T. Franco, Jerry Ware)....Pages 37-54 Risk of Thrombosis in Cancer: Clinical Factors and Role of Primary Prophylaxis (Joanna Roopkumar, Alok A. Khorana)....Pages 55-68 Biomarkers of Cancer-Associated Thromboembolism (Anjlee Mahajan, Ted Wun)....Pages 69-85 Thrombotic Risk from Chemotherapy and Other Cancer Therapies (M. D. Debbie Jiang, M. D. Alfred Ian Lee)....Pages 87-101 Treatment of Venous Thromboembolism in Cancer. Historical Perspective and Evolving Role of the Direct Oral Anticoagulants (Marc Carrier, Gerald Soff, Grégoire Le Gal)....Pages 103-115 Etiology and Management of Upper-Extremity Catheter-Related Thrombosis in Cancer Patients (Anita Rajasekhar, Michael B. Streiff)....Pages 117-137 Management of Thrombocytopenia in Cancer Patients (Jodi V. Mones, Gerald Soff)....Pages 139-150 Microangiopathy in Cancer: Causes, Consequences, and Management (Mari R. Thomas, Marie Scully)....Pages 151-158 Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (Kamya Sankar, Brady L. Stein, Raajit K. Rampal)....Pages 159-178 Anticoagulation in the Setting of Primary and Metastatic Brain Tumors (Charlene Mantia, Jeffrey I. Zwicker)....Pages 179-189 Bleeding Disorders Associated with Cancer (Simon Mantha)....Pages 191-203