Thrombolytic therapy in acute ischemic stroke 3 [Third International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke was held in Nara, Japan, on April 1 and 2, 1994

On the threshold of an exciting new era for acute stroke diagnosis and treatment, the Third International Symposium on Thrombolytic Therapy in Acute Ischemic Stroke was held in Nara, Japan, in April 1994. The symposium brought together some 200 basic and clinical scientists for presentations and discussions of issues vital to the understanding of thrombolytic therapy. This volume compiles the major presentations of the symposium, with attention to applications of new diagnostic measures such as diffusion and perfusion MRI, contrast-enhanced transcranial Doppler and angioscopy. Other presentations examine the mechanisms of ischemia/reperfusion injury, hemorrhagic transformation, and reocclusion, with reviews of recent developments in thrombolytic agents. The proceedings of the symposium will be of special interest to researchers, physicians, and students in the fields of neurology, neurosurgery, and nuclear medicine, as well as those in pharmacology, critical care medicine, and related fields. Front Matter....Pages II-XV Front Matter....Pages 1-1 Time Course of Leukocyte Influx Following Middle Cerebral Artery Occlusion in the Wistar Rat....Pages 3-9 The Role of P-Selectin and ICAM-1 During Focal Brain Ischemia/Reperfusion....Pages 10-18 Delayed Neuronal Death and Ischemic Tolerance....Pages 19-28 Positron Emission Tomography in Patients with an Acute Embolic Occlusion of the Carotid Artery....Pages 29-36 Front Matter....Pages 39-39 Early Findings of Computed Tomography and Angiography in Acute Stroke and Thrombolytic Therapy....Pages 41-46 Role of Extracranial Ultrasound and Angioscopy in Thrombolytic Therapy....Pages 47-55 Transcranial Contrast-Enhanced Color-Flow Imaging....Pages 56-60 Value of Single Photon Emission Computed Tomography in Acute Stroke Therapeutic Trials....Pages 61-71 Correlation of SPECT with Angiography in Early Ischemic Stroke....Pages 72-80 New MR Technologies for Diagnosis of Acute Ischemic Stroke: MR Angiography, Diffusion, and Perfusion Imaging....Pages 81-85 Front Matter....Pages 39-39 Behavioral Syndromes in Early Right Middle Cerebral Artery Territory Stroke....Pages 93-98 Symptoms and Signs in Early Vertebrobasilar Territory Stroke....Pages 99-106 Subtypes of Infarction and Their Differentiation: Relevance to Thrombolytic Therapy and Early Randomization....Pages 107-109 Front Matter....Pages 113-113 Applications of Diffusion-Weighted Magnetic Resonance Imaging for Stroke Diagnosis and Treatment....Pages 115-123 Strategies of Early Patient Recruitment: A Community-Based Study....Pages 124-129 Neuro-Intensive Care Units and Management of Acute Stroke Patients: Benefits and Limitations....Pages 130-140 Brain-Oriented Intensive Care: Standardization of Postresuscitation Therapy....Pages 141-151 Meta-Analysis of Data from Trials of Thrombolytic Therapy in Acute Ischemic Stroke....Pages 152-158 Front Matter....Pages 163-163 Thrombolytic Therapy in Acute Ischemic Stroke: Combination Therapy with Antiplatelet and Anticoagulant Agents....Pages 165-173 Combination Therapy with Cytoprotective Agents....Pages 174-181 Front Matter....Pages 163-163 New Thrombolytic Agents: Basic Development....Pages 182-187 Front Matter....Pages 191-191 The NINDS t-PA Stroke Trial: Progress Report....Pages 193-197 Is Thrombolysis Useful for Acute Stroke Patients? The Experience of the MAST-I Study....Pages 198-205 The Multicenter Acute Stroke Trial (MAST)—Thrombolysis Study: Study Design and Progress Report....Pages 206-213 Australian Streptokinase Trial: Progress Report....Pages 214-217 European Cooperative Acute Stroke Study: Trial Protocol....Pages 218-222 Clinical Efficacy and Safety of Intravenous Tissue Plasminogen Activator in Acute Embolic Stroke: A Randomized, Double-Blind, Dose-Comparison Study of Duteplase....Pages 223-229 Front Matter....Pages 233-233 Delayed Recanalization and Reocclusion Following Thrombolysis for Acute Stroke....Pages 235-241 Intracranial Hemorrhage in Association with Thrombolysis: Multiple Causes and Risk Factors (No Simple Answer)....Pages 242-253 Mechanisms of Fibrinolysis-Associated Hemorrhagic Transformation....Pages 254-266 Front Matter....Pages 233-233 Plasminogen Plus rt-PA Improves Intraarterial Thrombolytic Therapy in Acute Ischemic Stroke....Pages 271-278 Intraarterial Therapy in Acute Ischemic Stroke....Pages 279-287 Intravenous Thrombolytic Therapy for Acute Ischemic Stroke....Pages 288-293 Interventional Neurovascular Techniques in Acute Thrombolytic Therapy for Stroke....Pages 294-300 “Central” Intraarterial Thrombolysis Using a Newly Developed Low Friction Guidewire/Catheter System....Pages 301-306 Front Matter....Pages 309-309 Microvascular Leukocyte Plugging in Evolving Brain Infarction in Humans....Pages 311-314 Recombinant Tissue Plasminogen Activator and Mutant rt-PA: Binding Kinetics and Cytotoxicity on Brain Endothelial Cells—Relevance to Brain Hemorrhage....Pages 315-322 Reperfusion in Patients with the “Spectacular Shrinking Deficit” Demonstrated by 99m Tc-hexamethylpropyleneamine Oxime Single Photon Emission Computed Tomography....Pages 323-326 Reliability of the Barthel Index Outcome Measure Selected for the NINDS t-PA Stroke Trial....Pages 327-334 Acute Local Fibrinolysis for Embolic Middle Cerebral Artery Occlusion Using Recombinant Tissue Type Plasminogen Activator....Pages 335-338 Front Matter....Pages 309-309 Intracarotid Recombinant Tissue Plasminogen Activator in Acute Carotid Artery Territory Stroke....Pages 339-342 Thrombolytic Therapy of Basilar Artery Occlusion: Preconditions for Recanalization and Good Clinical Outcome....Pages 343-348 Back Matter....Pages 355-357