Thermoradiotherapy and Thermochemotherapy: Volume 2: Clinical Applications (Medical Radiology)

This volume summarizes clinical practice and the results achieved with combined thermoradiotherapy and thermochemotherapy for tumors of the brain, breast, chest wall, head and neck, esophagus, upper and lower abdomen, genitourinary tract, soft tissues and eye, in both adults and children. Special applications, such as intracavitary, interstitial, intraoperative and whole-body hyperthermia, are addressed in detail. Multicenter trials and data analysis receive extensive consideration. Front Matter....Pages I-X Front Matter....Pages 1-1 Clinical Rationale for Thermoradiotherapy....Pages 3-23 Clinical Rationale for Thermochemotherapy....Pages 25-33 Thermoradiotherapy for Advanced and Recurrent Breast Tumours....Pages 35-48 Thermoradiotherapy for Head and Neck Tumors....Pages 49-67 Thermoradiotherapy of Malignant Melanoma....Pages 69-83 Thermoradiotherapy combined with Chemotherapy for Esophageal Tumors....Pages 85-94 Thermoradiotherapy for Upper Abdominal Tumors....Pages 95-104 Thermoradiotherapy for Tumors of the Lower Gastrointestinal Tract....Pages 105-119 Thermoradiotherapy for Genitourinary and Gynecological Tumors....Pages 121-132 Thermoradiotherapy of Uterine Carcinoma....Pages 133-146 Thermoradiotherapy and Thermochemotherapy for Sarcomas....Pages 147-158 Thermoradiotherapy for Brain Tumors....Pages 159-173 Thermoradiotherapy for Eye Tumors....Pages 175-185 Thermoradiotherapy and Thermochemotherapy for Pediatric Tumors....Pages 187-205 Clinical Practice of Interstitial Thermoradiotherapy....Pages 207-262 Clinical Practice of Intracavitary Thermoradiotherapy....Pages 263-274 Clinical Practice of Intraoperative Thermoradiotherapy....Pages 275-302 Clinical Practice of Whole-Body Hyperthermia: New Directions....Pages 303-322 Clinical Practice of Hyperthermic Extremity Perfusion In Combination with Radiotherapy and Chemotherapy....Pages 323-345 Front Matter....Pages 347-347 Prognostic Factors in Thermoradiotherapy Clinical Trials....Pages 349-360 Front Matter....Pages 347-347 Considerations for Hyperthermia Clinical Trials Design....Pages 361-372 Review of Biostatistical Methods and Interpretation of Hyperthermia Clinical Trials....Pages 373-383 Standardized Thermoradiotherapy Treatment Documentation....Pages 385-393 Appendix:Tabulation of Parameters for Hyperthermic Data Evaluation....Pages 395-403 Back Matter....Pages 405-421 Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com­ plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper­ thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina­ tion with radiation therapy and/or chemotherapy, providing a comprehensive over­ view of its use in cancer management.