Therapy of Parkinson's Disease, Third Edition (Neurological Disease and Therapy)

A comprehensive review of current tactics in the therapeutic management of Parkinson's disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The well-timed Third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsonian medications, ablative surgical options, deep brain stimulation, nonmotor symptom treatments, nonmedical strategies, and investigational therapies. Doody Review Services Reviewer: Stephen G. Reich, MD(University of Maryland School of Medicine) Description: The comprehensive scope of the third edition of this book is reflected in an opening chapter on the history of medical therapy for Parkinson's disease (PD) and a closing chapter on neural stem cell therapy. In between are scholarly, well-balanced chapters on all currently available medical and surgical therapies for PD. There are equally high-quality chapters on imaging, non-motor symptoms, nutrition, physical, occupation, and speech therapy, as well as nice coverage of emerging/experimental therapies. Particularly appealing and user-friendly is the division of chapters into an outline format; most have a well-written, balanced, "take-home message" conclusion. Purpose: The editors have, with few exceptions, succeeded in their goal of providing a thorough, up-to-date reference for physicians and other healthcare professionals who care for patients with Parkinson's disease. A new edition is well-justified in light of recent advances in medical and surgical therapy of PD. Furthermore, this book is sensitive to the growing complexities of caring for patients, such as deciding on initial therapy, determining who is a surgical candidate, the impact of non-motor symptoms on quality-of-life, and complications of advancing PD, including dementia and psychosis. Audience: The book is targeted primarily to neurologists, but its broad coverage makes it an equally valuable resource to almost everyone who cares for patients with PD, including neurosurgeons, therapists, and primary care practitioners. The editors and authors are recognized experts and this is reflected in the authoritative, comprehensive, and well-written chapters. Features: A chapter is devoted to each of the currently available medical therapies for PD; separate chapters cover ablative surgery and deep brain stimulation at various sites. A novel feature are the chapters on subjects that are usually inadequately covered, such as electroconvulsive therapy for PD, radiosurgery, and transcranial magnetic stimulation as well as nutrition, physical, occupational, and speech therapy. Non-motor symptoms are addressed in chapters on autonomic disturbances, sleep, psychosis and dementia, anxiety and depression. Practitioners needing advice on treating drenching sweats, sensory symptoms (especially pain), and akathisia in PD will, surprisingly, not find it here. Other shortcomings include the lack of a chapter devoted to management of motor fluctuations, inattention to the explosion of information about quality of life in PD, and caring for caregivers. Assessment: If you have a previous edition of this book, you'll want to replace it with this edition. If you don't have a previous edition and care for patients with PD, this will be a welcome addition to your library. Book Cover......Page 1 Half-Title......Page 2 Title......Page 8 Copyright......Page 9 Foreword......Page 10 Preface......Page 12 Contents......Page 13 Contributors......Page 17 1. History of the Medical Therapy of Parkinson’ Disease......Page 25 2. History of Surgery for Parkinson’s Disease......Page 47 3. Clinical Assessments......Page 65 4. Magnetic Resonance Imaging and Positron Emission Tomography Investigations......Page 84 5. Is Levodopa Toxic?......Page 104 6. Levodopa Therapy......Page 115 7. Levodopa Infusion......Page 129 8. Bromocriptine......Page 142 9. Pergolide......Page 151 10. Pramipexole......Page 167 11. Ropinirole......Page 192 12. Cabergoline......Page 203 13. Apomorphine and Rotigotine......Page 218 14. Tolcapone......Page 230 15. Entacapone......Page 248 16. Anticholinergics......Page 259 17. Selegiline......Page 270 18. Amantadine......Page 282 19. Thalamotomy......Page 298 20. Pallidotomy......Page 320 21. Subthalamotomy......Page 333 22. Thalamic Deep Brain Stimulation......Page 349 23. Globus Pallidal Deep Brain Stimulation......Page 367 24. Subthalamic Nucleus Deep Brain Stimulation......Page 381 25. Cell Transplantation......Page 406 26. Electroconvulsive Therapy......Page 417 27. Functional Radiosurgery in Movement Disorders......Page 424 28. Transcranial Magnetic Stimulation......Page 433 29. Autonomic Nervous System Disturbances......Page 445 30. Sleep Problems......Page 458 31. Psychosis and Dementia......Page 469 32. Anxiety and Depression......Page 496 33. Diet and Nutrition......Page 522 34. Speech, Voice, and Swallowing Disorders......Page 538 35. Physical and Occupational Therapy......Page 561 36. New and Experimental Drug Treatments......Page 572 37. Mitochondrial Dysfunction and Therapies......Page 590 38. Trophic Factors: Potential Therapies......Page 600 39. Neural Stem Cell Therapy......Page 613 Index......Page 641 About the Editors......Page 658 History of the medical therapy of Parkinson'[s] Disease History of surgery for Parkinson's Disease Clinical assessments Magnetic resonance imaging and positron emission tomography investigations Is levodopa toxic? Levodopa therapy Levodopa infusion Bromocriptine Pergolide Pramipexole Ropinirole Cabergoline Apomorphine and rotigotine Tolcapone Entacapone Anticholinergics Selegiline Amantadine Thalamotomy Pallidotomy Subthalamotomy Thalamic deep brain stimulation Globus pallidal deep brain stimulation Subthalamic nucleus deep brain stimulation Cell transplantation Electroconvulsive therapy Functional radiosurgery in movement disorders Transcranial magnetic stimulation Autonomic nervous system disturbances Sleep problems Psychosis and dementia Anxiety and depression Diet and nutrition Speech, voice, and swallowing disorders Physical and occupational therapy New and experimental drug treatments Mitochondrial dysfunction and therapies Trophic factors: potential therapies Neural stem cell therapy. A comprehensive review of current tactics in the therapeutic management of Parkinson2s disease, this volume offers summaries of salient research findings as well as contemporary attitudes and practical advice from field specialists. The third Edition is expanded and topically reorganized to register trends and progress in anti-parkinsonian medications, ablative surgical options, deep brain stimulation, nonmotor symptom treatments, nonmedical strategies, and investigational therapies. James Parkinson wrote in his historic Essay on the Shaking Palsy, published in 1817 (1), that there was "sufficient reason for hoping that some remedial process may ere long be discovered, by which, at least, the progress of the disease may be stopped ... although the removing of the effects already produced, might be hardly to be expected."