The Vascular Endothelium II (Handbook of Experimental Pharmacology (176/II))

This volume offers a comprehensive review of recent advances in research on the vascular endothelium. It provides a historical background and a guide for future directions in research. This book comprises 20 chapters by a diverse group of authors who have all made significant contributions to the field of research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of specific pathologies and their treatment. Also discussed are various gene therapy strategies for the treatment of vascular pathologies. The Vascular Endothelium II is a detailed and wide ranging work that provides a complete representation of the state of knowledge and practice in the early 21st century. V.1. Normal Endothelium -- Functional Ultrastructure Of The Vascular Endothelium: Changes In Various Pathologies -- Development Of The Endothelium -- Transport Across The Endothelium: Regulation Of Endothelial Permeability -- Calcium Signalling In The Endothelium -- Eicosanoids And The Vascular Endothelium -- Nitric Oxide And The Vascular Endothelium -- Angiotensin, Bradykinin And The Endothelium -- Endothelin -- Volume 2. Haemostasis -- Vascular Endothelium And Blood Flow -- Biomechanical Modulation Of Endothelial Phenotype: Implications For Health And Disease -- Leukocyte-endothelial Interactions In Health And Disease -- Endothelial Cell Dysfunction, Injury And Death -- Principles And Therapeutic Implications Of Angiogenesis, Vasculogenesis And Arteriogenesis -- Endothelial Cell Senescence -- Vascular Endothelium In Hypertension -- Vascular Endothelium And Atherosclerosis -- Endothelial Cells And Cancer -- Gene Therapy: Role In Myocardial Protection. Editors, Salvador Moncada And Annie Higgs. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Haemostasis....Pages 1-41 Vascular Endothelium and Blood Flow....Pages 43-78 Biomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease....Pages 79-95 Leucocyte-Endothelial Interactions in Health and Disease....Pages 97-133 Endothelial Cell Dysfunction, Injury and Death....Pages 135-156 Principles and Therapeutic Implications of Angiogenesis, Vasculogenesis and Arteriogenesis....Pages 157-212 Endothelial Cell Senescence....Pages 213-248 The Vascular Endothelium in Hypertension....Pages 249-283 Vascular Endothelium and Atherosclerosis....Pages 285-306 Endothelial Cells and Cancer....Pages 307-334 Gene Therapy: Role in Myocardial Protection....Pages 335-350 This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.