The Ubiquitous Roles of Cytochrome P450 Proteins (Metal Ions in Life Sciences, Volume 3)

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series "Metal Ions in Life Sciences". There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments. As a result the reader will find a systematic account of new results in this exciting research area. The table of contents gives an idea on the wide span of chapters, starting with overviews and the presentation of specific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems. Looking across the tree of life, it is amazing to find cytochrome P450 proteins represented in all life forms. Volume 3, devoted solely to the vital and still expanding research area concerning P450s, offers in 17 stimulating chapters written by 36 internationally recognized experts an authoritative and timely account of this fascinating subject. The Ubiquitous Roles of Cytochrome P450 Proteins highlights, supported by nearly 2700 references, more than 20 tables and 190 illustrations, the function of these versatile catalysts which act as monooxygenases and insert an oxygen atom from dioxygen into a substrate molecule oxidizing it. P450s are important in the biosynthesis of hormones and signaling molecules as well as in xenobiotic metabolism and detoxification ranging from pharmaceuticals in humans to toxic substances in insects and plants. Mechanistic aspects and the design and engineering of P450 systems for biotechnological applications are also covered. MILS-3 is essential for scientists working in the wide range from bioinorganic chemistry all the way through to medicine including the clinic. This volume encompasses the breadth of research efforts focused on P450s from structure to function including an appreciation of the diversity and complexity of the biotransformations they catalyze. The introductory Chapter 1, setting the scene, explores the many different levels at which these P450 enzymes (and their respective genes) have diverged in the process of evolution to yield the plethora of enzymes that are now termed "P450 monooxygenases". This broad and unprecedented reactivity of P450 enzymes which contain a heme iron center (most commonly iron(III)protoporphyrin IX) with a deprotonated cysteine side chain providing the fifth ligand to iron, has challenged the "biomimetic community". Indeed, much has been accomplished over the past five decades, e.g., regarding the understanding of the unusual activation of paramagnetic dioxygen by reductive oxygen clea Diversities And Similarities In P450 Systems: An Introduction / Mary A. Schuler And Stephen G. Sligar -- Structural And Functional Mimics Of Cytochromes P450 / Wolf-d. Woggon -- Structures Of P450 Proteins And Their Molecular Phylogeny / Thomas L. Poulos And Yergalem T. Meharenna -- Aquatic P450 Species / Mark J. Snyder -- The Electrochemistry Of Cytochrome P450 / Alan M. Bond, Barry D. Fleming, And Lisandra L. Martin -- P450 Electron Transfer Reactions / Andrew K. Udit, Stephen M. Contakes, And Harry B. Gray -- Leakage In Cytochrome P450 Reactions In Relation To Protein Structural Properties / Christiane Jung -- Cytochromes P450: Structural Basis For Binding And Catalysis / Konstanze Von König And Ilme Schlichting -- Beyond Heme-thiolate Interactions: Roles Of The Secondary Coordination Sphere In Cytochrome P450 Systems / Yi Lu And Thomas D. Pfister -- Interactions Of Cytochrome P450 With Nitric Oxide And Related Ligands / Andrew E. Munro, Kirsty J. Mclean, And Hazel M. Girvan -- Cytochrome P450-catalyzed Hydroxylations And Epoxidations / Roshan Perera [and Others] -- Cytochrome P450 And Steroid Hormone Biosynthesis / Rita Bernhardt And Michael R. Waterman -- Carbon-carbon Bond Cleavage By P450 Systems / James J. De Voss And Max J. Cryle -- Design And Engineering Of Cytochrome P450 Systems / Stephen G. Bell [and Others] -- Chemical Defense And Exploitation: Biotransformation Of Xenobiotics By Cytochrome P450 Enzymes / Elizabeth M.j. Gillam And Dominic J.b. Hunter -- Drug Metabolism As Catalyzed By Human Cytochrome P450 Systems / F. Pter Guengerich -- Cytochrome P450 Enzymes: Observations From The Clinic / Peggy L. Carver. Edited By Astrid Sigel, Helmut Sigel, And Roland K.o. Sigel. Includes Bibliographical References And Index.

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series "Metal Ions in Life Sciences".

There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments.

As a result the reader will find a systematic account of new results in this exciting research area. Thetable of contents gives an idea on the wide span of chapters, starting with overviews and the presentation ofspecific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems.