The Ubiquitin System in Health and Disease (Ernst Schering Foundation Symposium Proceedings Book 1)

The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book. Crosstalk Between The Sumo And Ubiquitin Pathways -- Tale Of Two Giant Proteases -- Molecular Genetics Of The Ubiquitin-proteasome System: Lessons From Yeast -- Less Is More: How Protein Degradation Regulates Muscle Development -- Transcriptional Control And The Ubiquitin-proteasome System -- Ubiquitination Of Myc: Proteasomal Degradation And Beyond -- Regulation Of Apoptosis And Cytokinesis By The Anti-apoptotic E2/e3 Ubiquitin-ligase Bruce -- Dissecting Roles Of Ubiquitination In The P53 Pathway -- Regulation Of T Cell Differentiation And Allergic Responses By The E3 Ubiquitin Ligase Itch -- Approaches To Discovering Drugs That Regulate E3 Ubiquitin Ligases -- Inhibiting Hdm2 And Ubiquitin-activating Enzyme: Targeting The Ubiquitin Conjugating System In Cancer. Editors, S. Jentsch, B. Haendler. Includes Bibliographical References. The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.