The Superoxide-Forming NADPH Oxidase of Phagocytes: An Enzyme System Regulated by Multiple Mechanisms (Reviews of Physiology, Biochemistry and Pharmacology)

The book reviews the literature on the regulation of NADPH oxidase, which is controversial in many areas, and refers specifically to relevant publications from the past 4 years. Main topics are catalytical properties, cofactor requirements and structural components of NADPH oxidase, activation of NADPH oxidase, inhibition of NADPH oxidase, reconstitution and regulation of NADPH oxidase activity in cell-free systems, and pathology of NADPH oxidase. Introduction....Pages 1-3 NADPH Oxidase: A superoxide-forming enzyme system....Pages 5-18 Activation of NADPH Oxidase....Pages 19-145 Inhibition of NADPH Oxidase....Pages 147-176 Reconstitution and regulation of NADPH Oxidase activity in cell-free systems....Pages 177-202 Pathology of NADPH Oxidase....Pages 203-217 Age- and sex-ralated alterations of the activity of NADPH Oxidase....Pages 219-220 Concluding remarks....Pages 221-223 This text reviews the literature on the regulation of NADPH oxidase and refers specifically to relevant publications from the past four years. The main areas considered include catalytical properties, cofactor requirements and structural components of NADPH oxidase and pathology of NADPH oxidase.