The Smoothened Receptor in Cancer and Regenerative Medicine (Topics in Medicinal Chemistry Book 16)

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. Front Matter....Pages i-vii Smoothened Inhibitors in Cancer....Pages 1-11 Canonical and Non-Canonical Hedgehog Signaling Pathways: Role of G Proteins....Pages 13-42 Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design....Pages 43-107 Receptor Modifications in Hedgehog Regulation....Pages 109-125 Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery....Pages 127-146 Smoothened, Stem Cell Maintenance and Brain Diseases....Pages 147-171 The Role of Smoothened and Hh Signaling in Neovascularization....Pages 173-205 Back Matter....Pages 207-210