The Serpin Family : Proteins with Multiple Functions in Health and Disease

"The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses." -- Back cover Front Matter....Pages i-viii The Human SERPIN Repertoire and the Evolution of 14q32.1 and 18q21.3 Gene Clusters....Pages 1-14 Serpins in Plants....Pages 15-28 Peptides as Modulators of Serpin Action....Pages 29-45 Genomic and Functional Studies of Serpins from Basal Vertebrates Provide Insight into the Evolution of Haemostatic Control and Blood Pressure Regulation....Pages 47-57 Regulation of Neutrophil Serine Proteases by Intracellular Serpins....Pages 59-76 SerpinB1: A Global Regulator of Neutrophil Homeostasis....Pages 77-91 Serpins in T Lymphocyte Immunity and Blood Development....Pages 93-106 Plasminogen Activator Inhibitor Type-2 (PAI-2)/SerpinB2: A Unique Multifunctional Serpin....Pages 107-126 Maspin Is a Multifunctional Tumor-Suppressing Serpin....Pages 127-152 Protein C Inhibitor....Pages 153-177 Protease Nexin-1: A Serpin Involved in Pathophysiology....Pages 179-196 PEDF in the Retina....Pages 197-212 Defining the Proteostasis Network Responsible for Managing the Fate of Newly Synthesized Alpha1-Antitrypsin....Pages 213-228 Endoplasmic Reticulum Stress and the Protein Overload Response in the Serpinopathies....Pages 229-251 Serpins in Caenorhabditis elegans ....Pages 253-268 The Dual Role of Serpins and Tissue-Type Plasminogen Activator During Stroke....Pages 269-292 Serpins, Viruses, and the Virome: New Directions in Therapy....Pages 293-326 Back Matter....Pages 327-329